| Movie | 1980 | Punk and Its Aftershocks | Self | |
| Movie | 2005 | The Pretenders: No Turn Left Unstoned | Self | |
| Movie | 2013 | Basically, Johnny Moped | Self | |
| Movie | 1998 | The Righteous Babes | Self | |
| Movie | 1988 | A Reggae Session | Self | |
| Movie | 2003 | Pretenders - Loose in L.A. | Herself - Vocals & Guitar | |
| Movie | 1999 | One Love: The Bob Marley All-Star tribute | Self - Perfomer | |
| Movie | 2023 | The Pretenders: Chrissie Hynde or Rock Life | Herself | |
| Movie | 2023 | The Pretenders: Radio 2 in the Park | | |
| Movie | 1990 | One World, One Voice | Self | |
| Movie | 1972 | Bob Dylan: The 30th Anniversary Concert Celebration | Self | |
| Movie | 2022 | Taylor Hawkins Tribute Concert | Self | |
| Movie | 2021 | Tomorrow Is a Long Time: Chrissie Hynde Sings Bob Dylan | Self | |
| Movie | 2022 | McEnroe | Self | |
| Movie | N/A | Are We Not Men? | Self | |
| Movie | 1988 | The Nelson Mandela 70th Birthday Concert | Self | |
| Movie | 2015 | The Damned: Don't You Wish That We Were Dead | Self | |
| Movie | 2018 | Here to be Heard: The Story of The Slits | Self (archive footage) | |
| Movie | 2013 | Best Of Night Of The Proms vol. 6 | | |
| Movie | 2015 | Kylie Minogue: A Kylie Christmas Live at the Royal Albert Hall | Self | |
| Movie | 2016 | Promises and Lies: The Story of UB40 | | |
| Movie | 2010 | The Pretenders - Live in London | Herself - vocals, guitar | |
| Movie | 2005 | New York Doll | Self | |
| Movie | 2005 | Punk: Attitude | Self | |
| Movie | 2017 | Two Sevens Clash: Dread Meets Punk Rockers | Self | |
| Movie | 2017 | Alone With Chrissie Hynde | Herself | |
| Movie | 2003 | Rugrats Go Wild | Siri (voice) | |
| Movie | 2006 | Happy Feet | Michelle (voice) | |
| Movie | 1985 | Live Aid | Self | |
| Movie | 2010 | Search and Destroy: Iggy & The Stooges' Raw Power | Self | |
| Movie | 2002 | Jeff Buckley: Everybody Here Wants You | Self | |
| Movie | 2004 | Rod Stewart: One Night Only! (Live at the Royal Albert Hall) | Self - Guest Star | |
| Movie | 2015 | Girls in Bands at the BBC | Self (archive footage) | |
| Movie | 1981 | The Pretenders: Live at Köln | | |
| Movie | 2006 | The Pretenders - With Friends | Self | |
| Movie | 2017 | The Pretenders at Austin City Limits | Self | |
| Movie | 1984 | Pretenders Live in Dortmund | | |
| Movie | 2006 | The Pretenders: Pirate Radio (1979-2005) | | |
| Movie | 1999 | Lilith on Top | | |
| Movie | 1998 | Burt Bacharach: One Amazing Night | Self | |
| Movie | 2005 | Live Aid: 20 Years Ago Today | Self | |
| Movie | 2010 | Best of Night of the Proms Vol. 4 | self | |
| Movie | 2005 | Best of Night of the Proms Vol. 1 | Self | |
| Movie | 1981 | Concerts for the People of Kampuchea | Self | |
| Movie | 1986 | Women in Rock | Self | |
| Movie | 2025 | Lilith Fair: Building a Mystery | Self | |
| Movie | 2000 | The Pretenders - Greatest Hits | | |
| TV Show | 1994 | Friends | Stephanie Schiffer | 1 |
| TV Show | 2000 | Da Ali G Show | | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 1 |
| TV Show | 1978 | The Kenny Everett Video Show | | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Musical Guest | 1 |
| TV Show | 1998 | The Young Person's Guide to Becoming a Rock Star | Self | 1 |
| TV Show | 1996 | Never Mind the Buzzcocks | Self | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2002 | CMT Crossroads | Self | 1 |
| TV Show | 1998 | V.I.P. | Self | 1 |
| TV Show | 1980 | Fridays | Self - Musical Guest | 1 |
