| Movie | 1993 | Short Cuts | Vern Miller | |
| Movie | 2022 | Retour vers le futur : Voyage dans le temps, American Dream & rock'n'roll | Self | |
| Movie | 2002 | .com for Murder | Agent Matheson | |
| Movie | 2000 | Duets | Ricky Dean | |
| Movie | 2005 | Huey Lewis & the News: Live at 25 | Self - Lead Vocals, Harmonica | |
| Movie | 1996 | The Rocker: A Portrait of Phil Lynott | Self | |
| Movie | 1998 | Shadow of Doubt | Al Gordon | |
| Movie | 2009 | Looking Back to the Future | Self (archive footage) | |
| Movie | 2024 | The Greatest Night in Pop | Self | |
| Movie | 1987 | Huey Lewis and the News - All the Way Live | | |
| Movie | 1998 | Sphere | Helicopter Pilot | |
| Movie | 1990 | The Real Story of Humpty Dumpty | Scratch (voice) | |
| Movie | 1984 | Huey Lewis and the News: Rockpalast Live | Self - Lead Vocals, Harmonica | |
| Movie | 1985 | Huey Lewis and the News: The Heart of Rock and Roll | Self - Vocals & Harmonica | |
| Movie | 1979 | Rockpile: Born Fighters | Self | |
| Movie | 1987 | Huey Lewis and the News: Before! | Self | |
| Movie | 2015 | Back in Time | Self | |
| Movie | 1986 | The Making of Back to the Future | Self | |
| Movie | 1978 | Thin Lizzy: Live and Dangerous | Self - Harmonica | |
| Movie | 2009 | Pocket Full of Soul: The Harmonica Documentary | Self | |
| Movie | 2013 | American Psycho with Huey Lewis and Weird Al | Self | |
| Movie | 1998 | Dead Husbands | Dalton Phillips (uncredited) | |
| Movie | 1985 | We Are the World: The Story Behind the Song | Self | |
| Movie | 2008 | Best of Night of the Proms Vol. 3 | Self | |
| Movie | 1985 | Back to the Future | High School Band Audition Judge (uncredited) | |
| Movie | 2020 | Phil Lynott: Songs for While I'm Away | Self | |
| Movie | 1987 | Amazon Women on the Moon | Huey Lewis (segment "Murray in Videoland") (uncredited) | |
| Movie | 2009 | O Melhor do Flash Back - 92 Clipes Para Recordar | Self (archive footage) | |
| Movie | 2020 | The Postal Service Zoom Auditions | Self | |
| Movie | 1995 | Land of Milk & Honey | | |
| Movie | 2007 | Graduation | Mike | |
| TV Show | 2003 | One Tree Hill | Jimmy James | 2 |
| TV Show | 2004 | The Tony Danza Show | Self | 2 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 2 |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 2013 | The Blacklist | Huey Lewis | 1 |
| TV Show | 1998 | The King of Queens | Huey Lewis | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Musical Guest | 1 |
| TV Show | 1999 | Where Are They Now? | Self | 1 |
| TV Show | 2010 | Hot in Cleveland | Johnny Revere | 5 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Musical Guest | 1 |
| TV Show | 1984 | MTV Video Music Awards | Self - Preshow Host | 1 |
| TV Show | 1984 | MTV Video Music Awards | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 1996 | The Rosie O'Donnell Show | Self - Guest | 1 |
| TV Show | 1987 | Going Live! | Self | 1 |
| TV Show | 2022 | Generation Gap | Self | 1 |
| TV Show | 2010 | Buccaneers & Bones | | 28 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 1 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 1982 | Champs-Elysées | Self | 1 |
| TV Show | 1963 | Viña del Mar International Song Festival | Self - Musical Guest | 1 |
| TV Show | 2020 | Reunited Apart | Self | 1 |
| TV Show | 2022 | Joe Montana: Cool Under Pressure | Self | 2 |
| TV Show | 1997 | Just Shoot Me! | Gary Rosenberg | 1 |
| TV Show | 1974 | Rockpalast | | 1 |
