Media | ||||
|---|---|---|---|---|
| Movie | 1997 | Bean | Stingo Wheelie | |
| Movie | 1997 | I Know What You Did Last Summer | Max Neurick | |
| Movie | 1989 | National Lampoon's Christmas Vacation | Russell 'Rusty' Griswold | |
| Movie | 2008 | Hancock | Jeremy | |
| Movie | 1998 | The Opposite of Sex | Jason Bock | |
| Movie | 2003 | Bookies | Jude | |
| Movie | 1988 | A Night in the Life of Jimmy Reardon | Toby Reardon | |
| Movie | 2011 | In Time | Borel | |
| Movie | 2001 | Morgan's Ferry | Darcy | |
| Movie | 2000 | Playing Mona Lisa | Arthur | |
| Movie | 2013 | CBGB | Terry Ork | |
| Movie | 1996 | Murder at My Door | Teddy McNair | |
| Movie | 2001 | Vanilla Sky | Peter Brown | |
| Movie | 1991 | Backfield in Motion | Tim Seavers | |
| Movie | 1993 | Sudden Fury | Daniel Hannigan | |
| Movie | 2018 | The Cleanse | Paul Berger | |
| Movie | 2000 | Bounce | Seth | |
| Movie | 2017 | Rings | Gabriel Brown | |
| Movie | 1987 | Murder Ordained | Doug Rule | |
| Movie | 2016 | Must See TV: An All Star Tribute to James Burrows | Self | |
| Movie | 1994 | Without Consent | Marty | |
| Movie | 1997 | Suicide Kings | Ira Reder | |
| Movie | 1989 | Prancer | Billy Quinn | |
| Movie | 2005 | Happy Endings | Miles (uncredited) | |
| Movie | 2004 | Chrystal | Barry | |
| Movie | 1990 | In Defense of a Married Man | Eric | |
| Movie | 2020 | The Little Dog Laughed | Alex | |
| Movie | 2019 | A Dog's Journey | Henry Montgomery | |
| Movie | 2009 | Table for Three | Ted | |
| TV Show | 1990 | American Dreamer | Danny Nash | 17 |
| TV Show | 1999 | Batman Beyond | Knux (voice) | 1 |
| TV Show | 2007 | The Big Bang Theory | Leonard Hofstadter | 279 |
| TV Show | 2005 | American Dad! | Arnie (voice) | 1 |
| TV Show | 1999 | Family Guy | Leonard Hofstadter (voice) | 1 |
| TV Show | 2003 | Hope & Faith | Jay | 3 |
| TV Show | 2005 | My Name Is Earl | Scott | 1 |
| TV Show | 1988 | Roseanne | David Healy | 92 |
| TV Show | 1992 | Billy | David MacGregor | 13 |
| TV Show | 2004 | LAX | Leland Pressman | 1 |
| TV Show | 1990 | Blossom | Jason | 1 |
| TV Show | 1989 | Hardball | 1 | |
| TV Show | 1991 | Civil Wars | Greg Stolbach | 1 |
| TV Show | 2015 | Lip Sync Battle | Self | 1 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 1990 | Blind Faith | John Marshall | 2 |
| TV Show | 2007 | Boulevard of Broken Dreams | Self (archive footage) | 1 |
| TV Show | 2018 | SciJinks | Himself - Host | 8 |
| TV Show | 2018 | The Conners | David Healy | 4 |
| TV Show | 1981 | Entertainment Tonight | Self | 2 |
| TV Show | 2020 | Stars in the House | Self | 1 |
| TV Show | 2010 | Conan | Self | 1 |
| TV Show | 1999 | The Norm Show | Dale Stackhouse | 2 |
| TV Show | 2004 | Entourage | Johnny Galecki | 3 |
Media | ||||
|---|---|---|---|---|
| Movie | 2018 | The Cleanse | Producer | Production |
| TV Show | 2018 | SciJinks | Executive Producer | Production |
