| Movie | 2002 | Ice Age | Manny (voice) | |
| Movie | 2006 | Ice Age: The Meltdown | Manny (voice) | |
| Movie | 2006 | Grilled | Maurice | |
| Movie | 2021 | Sam Morril: Full Capacity | | |
| Movie | 2009 | Ice Age: Dawn of the Dinosaurs | Manny (voice) | |
| Movie | 2005 | Earth to America | Self | |
| Movie | 2009 | Just for Laughs: Launching Pad | | |
| Movie | 2005 | To Be a Father | Self | |
| Movie | 2004 | Eulogy | Skip Collins | |
| Movie | 2004 | Welcome to Mooseport | Handy Harrison | |
| Movie | 2002 | Comedian | Self | |
| Movie | 2012 | Ice Age: Continental Drift | Manny (voice) | |
| Movie | 2006 | 95 Miles to Go | Himself | |
| Movie | 2011 | Ice Age: A Mammoth Christmas | Manny (voice) | |
| Movie | 2014 | Rob the Mob | Jerry Cardozo | |
| Movie | 2009 | Funny People | Ray Romano | |
| Movie | 2003 | Best of the Improv: Vol. 4 | Self | |
| Movie | 2012 | George Lopez: It's Not Me, It's You | Self | |
| Movie | 2001 | Laughing Out Loud: America's Funniest Comedians | Self (archive footage) | |
| Movie | 2014 | Showrunners: The Art of Running a TV Show | Self | |
| Movie | 2016 | Ice Age: Collision Course | Manny (voice) | |
| Movie | 2024 | Fly Me to the Moon | Henry Smalls | |
| Movie | 2015 | David Letterman: A Life on Television | Self - Host | |
| Movie | 2007 | The Grand | Fred Marsh | |
| Movie | 1996 | HBO Comedy Half-Hour: Ray Romano | | |
| Movie | 2015 | Cosmic Scrat-tastrophe | Manny (voice) | |
| Movie | 2016 | Ice Age: The Great Egg-Scapade | Manny (voice) | |
| Movie | 2010 | New York Street Games | Self | |
| Movie | 2017 | The Big Sick | Terry Gardner | |
| Movie | 2008 | The Last Word | Abel | |
| Movie | 2011 | Scrat's Continental Crack-Up: Part 2 | Manny (voice) | |
| Movie | 2011 | Dying to Do Letterman | Self | |
| Movie | 2019 | The Irishman | Bill Bufalino | |
| Movie | 2004 | The Dick Van Dyke Show Revisited | Himself (Host) | |
| Movie | 2017 | Where Have You Gone, Lou DiMaggio? | Self | |
| Movie | 2019 | Paddleton | Andy | |
| Movie | 2019 | Bad Education | Big Bob Spicer | |
| Movie | 1990 | Caesar's Salad | Good Cop | |
| Movie | 2019 | Ray Romano: Right Here, Around the Corner | Himself | |
| Movie | 2001 | America | A Tribute to Heroes | Self | |
| Movie | 2020 | Making 'The Irishman' | Self | |
| Movie | 1984 | Cruz de olvido | | |
| Movie | 2023 | Somewhere in Queens | Leo Russo | |
| Movie | 2026 | Ice Age 6 | Manny (voice) | |
| Movie | 2016 | Scrat: Spaced Out | Manny (voice, uncredited) | |
| Movie | 2009 | Unearthing the Lost World | Ice Age: Dawn of the Dinosaurs | Self | |
| TV Show | 1994 | Inside the Actors Studio | Self | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 4 |
| TV Show | 2004 | The Tony Danza Show | Self - Guest | 4 |
| TV Show | 2005 | Kathy Griffin: My Life on the D-List | Self | 1 |
| TV Show | 2005 | The Office | Merv Bronte | 1 |
| TV Show | 1996 | Everybody Loves Raymond | Ray Barone | 210 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 1995 | Dr. Katz, Professional Therapist | Ray (voice) | 7 |
| TV Show | 2002 | American Idol | Self - Interviewee / Audience Member | 1 |
| TV Show | 1999 | The Early Show | Self - Guest | 1 |
| TV Show | 1998 | The King of Queens | Ray Barone | 4 |
| TV Show | 2006 | Hannah Montana | Ray Romano | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 1 |
| TV Show | 2005 | Sit Down Comedy with David Steinberg | | 1 |
| TV Show | 2009 | Men of a Certain Age | Joe Tranelli | 22 |
| TV Show | 2017 | One Day at a Time | Brian | 1 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self - Guest | 3 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 2 |
| TV Show | 2013 | Norm Macdonald Live | Self | 1 |
| TV Show | 2023 | Bupkis | Ray Romano | 3 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 2 |
| TV Show | 2016 | Vinyl | Zak Yankovich | 10 |
| TV Show | 1999 | Rove | Self | 1 |
| TV Show | 2010 | The Green Room with Paul Provenza | Self | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 1 |
| TV Show | 1998 | Hollywood Squares | Self - Panelist | 5 |
| TV Show | 2017 | Get Shorty | Rick Moreweather | 27 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2023 | Bookie | 536 (Artie) (uncredited) | 2 |
| TV Show | 2010 | Parenthood | Hank Rizzoli | 43 |
| TV Show | 2024 | No Good Deed | Paul Morgan | 8 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 1 |
| TV Show | 2015 | Close Up with The Hollywood Reporter | Self | 1 |
| TV Show | 2013 | Hollywood Game Night | Self | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Presenter | 1 |
| TV Show | 2005 | The Reichen Show | Self - Guest | 1 |
| TV Show | 2022 | Celebrity Jeopardy! | Self | 1 |
| TV Show | 2021 | Made for Love | Herbert Green | 16 |
| TV Show | 1953 | The Oscars | Self | 1 |
| TV Show | 2009 | The Middle | Nicky Kohlbrenner | 2 |
| TV Show | 2014 | Off Camera with Sam Jones | Self | 1 |
| TV Show | 2010 | Conan | Self | 1 |
| TV Show | 2017 | Crashing | | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 1989 | The Simpsons | Ray Magini (voice) | 1 |
| TV Show | 2020 | Who Wants to Be a Millionaire | Self - Contestant | 3 |
| TV Show | 1998 | Hollywood Squares | | 5 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2019 | Today with Hoda & Jenna | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | | 1 |
| TV Show | 1996 | Full Frontal Comedy | self | 1 |
| TV Show | 1989 | 1/2 Hour Comedy Hour | self | 1 |
