| Movie | 2011 | Justin Bieber: Never Say Never | Self (archive footage) | |
| Movie | 2023 | Just for Laughs: The Gala Specials - Chelsea Handler | Self | |
| Movie | 2011 | Hop | Mrs. Beck | |
| Movie | 2012 | Fun Size | Joy DeSantis | |
| Movie | 2012 | This Means War | Trish | |
| Movie | 2013 | Call Me Crazy: A Five Film | Alex | |
| Movie | 2007 | Steam | Jacky | |
| Movie | 2022 | The Hall: Honoring the Greats of Stand-Up | Self | |
| Movie | 2014 | Chelsea Handler: Uganda Be Kidding Me Live | Herself | |
| Movie | 2024 | Prom Dates | Barb | |
| Movie | 2022 | Chelsea Handler: Revolution | Self | |
| Movie | 2024 | The Roast of Tom Brady | Self | |
| Movie | 2012 | The Glamorous Lie | Self (archive footage) | |
| Movie | 2017 | Double Dutchess: Seeing Double | | |
| Movie | 2017 | Gwen Stefani: You Make It Feel Like Christmas | Self | |
| Movie | 2019 | Still Laugh-In: The Stars Celebrate | Self | |
| Movie | 2019 | Hello, Privilege. It's Me, Chelsea | Self | |
| Movie | 2020 | Chelsea Handler: Evolution | Self | |
| Movie | 2006 | Cattle Call | Nikita | |
| Movie | 2025 | Chelsea Handler: The Feeling | Self | |
| TV Show | 2003 | Reno 911! | 'Pinky' the Drunk Driver | 1 |
| TV Show | 1997 | The View | Self | 4 |
| TV Show | 2001 | My Wife and Kids | | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | Herself | 6 |
| TV Show | 1997 | The Practice | Callie Fairbanks | 1 |
| TV Show | 1998 | Comedy Central Presents | | 1 |
| TV Show | 2009 | The Jay Leno Show | Self | 1 |
| TV Show | 2008 | Million Dollar Password | | 1 |
| TV Show | 2006 | The Greg Behrendt Show | | 1 |
| TV Show | 2018 | The Shop | Self | 1 |
| TV Show | 2011 | Whitney | Dr. Price | 2 |
| TV Show | 2012 | Are You There, Chelsea? | Sloane | 12 |
| TV Show | 2007 | Chelsea Lately | Herself - Host | 1186 |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self - Guest | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | | 2 |
| TV Show | 2015 | The Muppets | Self | 1 |
| TV Show | 2016 | Chelsea Does | Herself - Host | 4 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 4 |
| TV Show | 2019 | Tamron Hall | Self - Guest | 1 |
| TV Show | 2016 | Chelsea | Herself - Host | 120 |
| TV Show | 2018 | Red Table Talk | Self | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self | 1 |
| TV Show | 2011 | After Lately | Chelsea Handler | 24 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 1 |
| TV Show | 2009 | The Good Wife | Herself | 1 |
| TV Show | 1984 | MTV Video Music Awards | Self - Host | 1 |
| TV Show | 2020 | The Drew Barrymore Show | Self | 1 |
| TV Show | 2017 | The Gong Show | Self - Judge | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 6 |
| TV Show | 2010 | Who Do You Think You Are? | Self | 1 |
| TV Show | 2017 | Carpool Karaoke: The Series | Self | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 3 |
| TV Show | 2019 | The Kelly Clarkson Show | | 3 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 2 |
| TV Show | 2015 | Hot Ones | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 5 |
| TV Show | 2008 | Web Therapy | Chris Endicott | 3 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Host | 1 |
| TV Show | 2016 | To Tell the Truth | Self - Panelist | 2 |
| TV Show | 2001 | The Bernie Mac Show | Doris Flynt | 1 |
| TV Show | 2023 | Not Dead Yet | Sharon | 1 |
| TV Show | 1997 | The View | Self - Guest Co-Host | 1 |
| TV Show | 2019 | A Little Late with Lilly Singh | Self | 1 |
| TV Show | 2017 | Will & Grace | Donna Zimmer | 1 |
| TV Show | 2018 | Firing Line with Margaret Hoover | | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 5 |
| TV Show | 1996 | The Daily Show | Self - Guest Host | 4 |
| TV Show | 2022 | Password | Self - Celebrity Guest | 1 |
| TV Show | 2007 | Thank God You're Here | Self | 1 |
| TV Show | 2018 | 25 Words or Less | | 1 |
| TV Show | 2010 | Conan | Self | 2 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2001 | Critics Choice Awards | Self - Host | 1 |
| TV Show | 2018 | Lie Detector | Self | 1 |
| TV Show | 1999 | Mark Twain Prize | Self | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 3 |
| TV Show | 2023 | Off Script with The Hollywood Reporter | Self | 1 |
| TV Show | 2018 | What the Fit | Self | 1 |
| TV Show | 2011 | Web Therapy | Chris Endicott | 3 |
