| Movie | 2000 | The Flintstones in Viva Rock Vegas | Betty O'Shale | |
| Movie | 2002 | Ice Age | Rachel (voice) | |
| Movie | 2008 | The Rocker | Carol | |
| Movie | 2017 | She Loves Me: Behind the Curtain | Self | |
| Movie | 1983 | National Lampoon's Vacation | Cousin Vicki | |
| Movie | 2006 | Open Season | Giselle (voice) | |
| Movie | 2008 | Kit Kittredge: An American Girl | Miss May Dooley | |
| Movie | 2009 | Cirque du Freak: The Vampire's Assistant | Corma Limbs | |
| Movie | 2004 | Alfie | Dorie | |
| Movie | 2003 | Marci X | Lauren Farb | |
| Movie | 1999 | Go | Irene | |
| Movie | 2008 | A Muppets Christmas: Letters to Santa | Claire's Mom | |
| Movie | 1996 | Mrs. Winterbourne | Christine | |
| Movie | 2008 | Open Season 2 | Giselle (Voice) | |
| Movie | 2004 | A Christmas Carol | Ghost of Christmas Past / Streetlamp Lighter | |
| Movie | 2005 | Pretty Persuasion | Emily Klein | |
| Movie | 1991 | Stepping Out | Lynne | |
| Movie | 1991 | Women & Men 2: In Love There Are No Rules | Melba | |
| Movie | 1998 | Dance with Me | Patricia Black | |
| Movie | 2023 | Your Christmas or Mine 2 | Diane | |
| Movie | 2014 | Adult Beginners | Miss Jenn | |
| Movie | 2005 | Mom at Sixteen | Donna Cooper | |
| Movie | 1989 | When We Were Young | Linda Rosen | |
| Movie | 2015 | Pixels | First Lady Jane Cooper | |
| Movie | 2002 | Just a Walk in the Park | Rachel Morgan | |
| Movie | 2018 | Henchmen | Jane (voice) | |
| Movie | 2014 | Big Stone Gap | Sweet Sue Tinsley | |
| Movie | 1987 | Fatal Attraction | Christine | |
| Movie | 2000 | CatDog and the Great Parent Mystery | CatDog's Mother / Pussycat Catfield (voice) | |
| Movie | 2022 | From Dickinson, With Love | Mrs. Dickinson | |
| Movie | 2016 | Mildred and the Dying Parlor | Tutti | |
| Movie | 2016 | She Loves Me | Ilona | |
| Movie | 1983 | No Big Deal | Margaret | |
| Movie | 2017 | A Christmas Story Live! | Miss Shields | |
| Movie | 1993 | The Adventures of Young Indiana Jones: Mystery of the Blues | Dale Winter | |
| Movie | 2003 | When Zachary Beaver Came to Town | Heather | |
| Movie | 1992 | Liza Minnelli - Live from Radio City Music Hall | Self | |
| Movie | 2011 | Inside Story: National Lampoon's Vacation | Self | |
| Movie | 2020 | The Willoughbys | The Mother (voice) | |
| Movie | 2020 | Unbreakable Kimmy Schmidt: Kimmy vs. the Reverend | Jacqueline White | |
| Movie | 2020 | Unbreakable Kimmy Schmidt: Kimmy vs. the Music: A Live Singing Contest (That's Live) | Self | |
| Movie | 2020 | 30 Rock: A One-Time Special | Jenna Maroney | |
| Movie | 2021 | My Little Pony: A New Generation | Queen Haven (voice) | |
| Movie | 1997 | Hudson River Blues | | |
| Movie | N/A | The Man with the Bag | | |
| TV Show | 1997 | Ally McBeal | Elaine Vassal | 112 |
| TV Show | 1994 | Due South | Katherine Burns | 1 |
| TV Show | 1951 | Search for Tomorrow | T. R. Kendall | 3 |
| TV Show | 2001 | Friday Night with Jonathan Ross | Self - Guest | 1 |
| TV Show | 1996 | Early Edition | Dr. Amy Handelman | 1 |
| TV Show | 2002 | Everwood | Dr. Gretchen Trott | 2 |
| TV Show | 1992 | The Young Indiana Jones Chronicles | Dale Winter | 1 |
| TV Show | 1999 | Rocket Power | | 1 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Emma Spevak | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 4 |
| TV Show | 2006 | 30 Rock | Jenna Maroney | 138 |
| TV Show | 1995 | MADtv | Self | 1 |
| TV Show | 2002 | Hack | Mrs. Smith | 1 |
| TV Show | 1993 | Alex Haley's Queen | Jane | 3 |
| TV Show | 1997 | Christmas In Rockefeller Center | | 0 |
| TV Show | 2015 | Unbreakable Kimmy Schmidt | Jacqueline Voorhees / White | 51 |
| TV Show | 2015 | Younger | Annabelle Bancroft | 1 |
| TV Show | 2021 | Ziwe | Mom | 1 |
| TV Show | 1956 | Tony Awards | Self - Winner | 1 |
| TV Show | 2014 | BoJack Horseman | Honey Sugarman (voice) | 1 |
| TV Show | 2017 | Rapunzel's Tangled Adventure | Aunt Willow | 1 |
| TV Show | 1998 | CatDog | Mother (voice) | 1 |
| TV Show | 2015 | Difficult People | Lizzie McCormick | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest Co-Host | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 1 |
| TV Show | 2016 | Match Game | Self - Panelist | 11 |
| TV Show | 2012 | RuPaul's Drag Race All Stars | Self - Guest Judge | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 4 |
| TV Show | 1989 | The Simpsons | Zhenya (voice) | 1 |
| TV Show | 2021 | Schmigadoon! | Bobby Flanagan | 4 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 2024 | Elsbeth | Joann | 1 |
| TV Show | 2019 | Dickinson | Mrs. Dickinson | 30 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Spokesperson | 1 |
| TV Show | 2020 | Stars in the House | Self - Special Guest | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 2 |
| TV Show | 2009 | Modern Family | Donna Duncan | 3 |
| TV Show | 2005 | American Dad! | Charlotte (voice) | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | Veronica | 1 |
| TV Show | 2021 | Schmigadoon! | Countess Gabriele Von Blerkom | 1 |
| TV Show | 2020 | AJ and the Queen | Beth Barnes Beagle | 1 |
| TV Show | 2020 | Dishmantled | Herself - Judge | 1 |
| TV Show | 2009 | Late Night with Jimmy Fallon | Self | 1 |
| TV Show | 2021 | Name That Tune | Self - Host | 54 |
| TV Show | 1999 | Snoops | Jane Krakowski | 1 |
