| Movie | 1988 | Dangerous Liaisons | Azolan | |
| Movie | 1997 | Bean | Gareth | |
| Movie | 1988 | The Lair of the White Worm | Angus Flint | |
| Movie | 1983 | Local Hero | Danny Oldsen | |
| Movie | 2021 | National Theatre Live: Constellations | Roland | |
| Movie | 2006 | Aftersun | Jim | |
| Movie | 2014 | Doctor Who: Earth Conquest - The World Tour | Self | |
| Movie | 2011 | The Murder at Road Hill House | Samuel Kent | |
| Movie | 1997 | I Hate Christmas Too | Man | |
| Movie | 2021 | Quentin Blake – The Drawing of My Life | Self | |
| Movie | 2021 | The Suicide Squad | Thinker | |
| Movie | 2004 | Niceland (Population. 1.000.002) | John | |
| Movie | 1990 | December Bride | Young Sorleyson | |
| Movie | 1989 | Rosie the Great | The British Ambassador | |
| Movie | 2004 | Salvage | James Mulwray | |
| Movie | 2005 | House of 9 | Max Roy | |
| Movie | 2009 | In the Loop | Malcolm Tucker | |
| Movie | 2013 | World War Z | W.H.O. Doctor | |
| Movie | 2011 | Big Fat Gypsy Gangster | Peter Van Gellis | |
| Movie | 2005 | Wild Country | Father Steve | |
| Movie | 2006 | Pinochet in Suburbia | Andy McEntee | |
| Movie | 2002 | Solid Geometry | David Hunter | |
| Movie | 1998 | What Rats Won't Do | Tony | |
| Movie | 1996 | Giving Tongue | Duncan Fielding | |
| Movie | 2013 | The Fifth Estate | Alan Rusbridger | |
| Movie | 1985 | John and Yoko: A Love Story | George Harrison | |
| Movie | 2012 | The Cricklewood Greats | Himself | |
| Movie | 2013 | Inside the Mind of Leonardo | Leonardo da Vinci | |
| Movie | 2015 | Doctor Who: The Doctor's Meditation | The Doctor | |
| Movie | 1993 | Selling Hitler | Thomas Walde | |
| Movie | 1987 | Up Line | Scott Dare | |
| Movie | 1997 | Smilla's Sense of Snow | Birgo Lander | |
| Movie | 2003 | Mrs Caldicot's Cabbage War | Derek | |
| Movie | 1993 | Jealousy | John | |
| Movie | 2014 | Paddington | Reginald Curry | |
| Movie | 1993 | Soft Top Hard Shoulder | Gavin Bellini | |
| Movie | 2014 | Doctor Who: Last Christmas | The Doctor | |
| Movie | 1991 | Do Not Disturb | | |
| Movie | 1994 | Captives | Simon | |
| Movie | 1986 | God's Chosen Car Park | Everard | |
| Movie | 2013 | Doctor Who: The Day of the Doctor | The Doctor (12) (uncredited) | |
| Movie | 2002 | Max | David Cohn | |
| Movie | 1999 | The Greatest Store in the World | Mr. Whiskers | |
| Movie | 2001 | Hotel! | Hilton Gilfoyle | |
| Movie | 2004 | Modigliani | Jean Cocteau | |
| Movie | 2015 | Doctor Who: The Husbands of River Song | The Doctor | |
| Movie | 1992 | Mr. Wakefield's Crusade | Luke Wakefield | |
| Movie | 2014 | Doctor Who: Deep Breath | The Doctor (12) | |
| Movie | 2007 | The Rise of the Nutters | Malcolm Tucker | |
| Movie | 2016 | Doctor Who: Friend from the Future | The Doctor | |
| Movie | N/A | Lost for Words | The Tourist | |
| Movie | 1993 | Rik Mayall Presents: Micky Love | David Critchley | |
| Movie | 2014 | Doctor Who: Dark Water / Death in Heaven | The Doctor | |
| Movie | 2010 | Bistro | Max | |
| Movie | 2017 | Paddington 2 | Reginald Curry | |
| Movie | 1987 | The Story of a Recluse | Jamie Kirkwood | |
| Movie | 1982 | Living Apart Together | Joe | |
| Movie | 1992 | The Cloning of Joanna May | Isaac | |
| Movie | 2003 | Unconditional Love | DI Terry Machin | |
| Movie | 1985 | Turtle Diary | Assistant Keeper | |
| Movie | 1989 | Dream Baby | Willie | |
| Movie | 1988 | The Love Child | Dillon | |
| Movie | 2005 | The Best Man | Priest | |
| Movie | 1997 | Shooting Fish | Mr Gilzean | |
| Movie | 2013 | Doctor Who: The Time of the Doctor | The Doctor (12) | |
| Movie | 2017 | Doctor Who: Twice Upon a Time | The Doctor (12) | |
| Movie | 2018 | Christopher Robin | Rabbit (voice) | |
| Movie | 2019 | The Personal History of David Copperfield | Mr. Micawber | |
| Movie | 1995 | Runway One | Mick Galligan | |
| Movie | 2007 | Magicians | Mike Francis | |
| Movie | 2016 | Prison, My Parents & Me | Narrator | |
| Movie | 1996 | The Treasure Seekers | Jellicoe | |
| Movie | 2019 | How to See a Black Hole: The Universe's Greatest Mystery | Narrator | |
| Movie | 2019 | Martin's Close | Dolben | |
| Movie | 2014 | Doctor Who: The Ultimate Companion | Self / The Doctor (archive footage) | |
| Movie | 2016 | Doctor Who: The Return of Doctor Mysterio | The Doctor | |
| Movie | 2013 | Doctor Who Live: The Next Doctor | Self | |
| Movie | 2021 | Benediction | Siegfried Sassoon (Older) | |
| Movie | 2013 | Who's Afraid of Machiavelli? | Self - Presenter | |
| Movie | 1998 | Boswell's Boswell | James Boswell (voice) | |
| Movie | 2007 | Spinners and Losers | Malcolm Tucker | |
| Movie | 1992 | The Secret Agent | Mr Vladimir | |
| Movie | 2009 | A Portrait of Scotland | Self - Presenter | |
| Movie | 2004 | Napoleon's Waterloo | Narrator | |
| Movie | 1989 | Communicators From Hell | | |
| Movie | 2011 | The Natural World--Komodo: The Deadly Bite | | |
| Movie | 2022 | Riverwoods: An Untold Story | Narrator | |
| Movie | 2005 | Michael Powell | Narrator | |
| Movie | 2024 | Doctor Who at the Proms | The Doctor (12) (archive footage) | |
| Movie | 2025 | The Academy of Armando | Self | |
| Movie | 2025 | Doctor Who: Wish World & The Reality War | The Doctor (archive footage) (uncredited) | |
| Movie | 2020 | The Big Night In | Self | |
| TV Show | 1997 | Midsomer Murders | Laurence Barker | 1 |
| TV Show | 1988 | This Morning | Self - Guest | 1 |
| TV Show | 2003 | Peep Show | Professor Alistair MacLeish | 1 |
| TV Show | 2007 | Skins | Mark | 4 |
| TV Show | 2006 | The One Show | Self | 1 |
| TV Show | 2011 | The Natural World--Komodo: The Deadly Bite | voice actor | 1 |
| TV Show | 1997 | The History of Tom Jones: A Foundling | Lord Fellamar | 3 |
| TV Show | 1994 | The Vicar of Dibley | | 1 |
| TV Show | 1991 | Prime Suspect | Vernon 'Vera' Reynolds | 2 |
| TV Show | 2005 | The Thick of It | Malcolm Tucker | 21 |
| TV Show | 2001 | Judge John Deed | | 1 |
| TV Show | 1996 | Neverwhere | Islington | 5 |
| TV Show | 1996 | The Crow Road | Rory McHoan | 4 |
| TV Show | 2003 | Fortysomething | Dr. Ronnie Pilfrey | 6 |
| TV Show | 1983 | Natural World | Narrator | 2 |
| TV Show | 2006 | Aftersun | | 2 |
| TV Show | 2010 | Accused | Frank Ryland | 1 |
| TV Show | 2006 | Trawlermen | Narrator (voice) | 19 |
| TV Show | 2005 | Doctor Who | Caecilius | 1 |
| TV Show | 2010 | The Nativity | Balthazar | 4 |
| TV Show | 2011 | The Hour | Randall Brown | 6 |
| TV Show | 2005 | Doctor Who | The Doctor | 36 |
| TV Show | 1994 | The All New Alexei Sayle Show | | 6 |
| TV Show | 2011 | The Field of Blood | Dr. Pete | 2 |
| TV Show | 2014 | The Musketeers | Cardinal Richelieu | 10 |
| TV Show | 1979 | Minder | Ozzie | 1 |
| TV Show | 1987 | The Ruth Rendell Mysteries | Zeno Vedast | 3 |
| TV Show | 2009 | Getting On | Peter Healy | 3 |
| TV Show | 2001 | In Deep | Jeremy Church | 2 |
| TV Show | 1993 | Rik Mayall Presents | David Critchley | 1 |
| TV Show | 2004 | Sea of Souls | Gordon Fleming | 2 |
| TV Show | 1989 | Stay Lucky | | 1 |
| TV Show | 2001 | Waking the Dead | Lucien Calvin | 2 |
| TV Show | 2016 | Class | The Doctor | 1 |
| TV Show | 1999 | Psychos | | 1 |
| TV Show | 2007 | The Graham Norton Show | Self | 3 |
| TV Show | 2008 | The Penguins of Madagascar | Uncle Nigel (voice) | 1 |
| TV Show | 2012 | Punk Britannia | Narrator | 3 |
| TV Show | 2007 | Fallen Angel | Henry Appleton | 3 |
| TV Show | 2008 | Midnight Man | Trevor | 3 |
| TV Show | 2014 | Doctor Who Extra | Self | 12 |
| TV Show | 2024 | Criminal Record | DCI Daniel Hegarty | 16 |
| TV Show | 2022 | The Devil's Hour | Gideon Shepherd | 11 |
| TV Show | 2018 | Watership Down | Kehaar (voice) | 2 |
| TV Show | 2018 | James Cameron's Story of Science Fiction | Self | 4 |
| TV Show | 1991 | Selling Hitler | Thomas Walde | 5 |
| TV Show | 1989 | Agatha Christie's Poirot | Claude Langton | 1 |
| TV Show | 2006 | Torchwood | John Frobisher | 5 |
| TV Show | 2008 | Cold Blood | Self - Narrator | 1 |
| TV Show | 2006 | The Martians and Us | Narrator | 3 |
| TV Show | 1991 | Titmuss Regained | Ken Cracken | 3 |
| TV Show | 1990 | Have I Got News for You | Self | 1 |
| TV Show | 1989 | Shadow of the Noose | Robert Wood | 1 |
| TV Show | 2011 | Black Mirror | Older Cameron Walker | 1 |
| TV Show | 2002 | Foyle's War | Raymond Carter | 1 |
| TV Show | 2003 | The Afternoon Play | Billy Shannon | 1 |
| TV Show | 2008 | The Devil's Whore | King Charles I | 3 |
| TV Show | 1984 | Spectrum | Himself | 1 |
| TV Show | 1971 | A Ghost Story for Christmas | Dolben | 1 |
| TV Show | 2020 | Being Beethoven | Beethoven (voice) | 3 |
| TV Show | 2005 | A Ghost Story for Christmas | Dolben | 1 |
| TV Show | 1994 | Chandler & Co | Larry | 6 |
| TV Show | 2015 | Doctor Who: The Fan Show | | 1 |
| TV Show | 2009 | 10 Minute Tales | The Man | 1 |