| Movie | 2023 | Marc Maron: From Bleak to Dark | Self | |
| Movie | 2022 | DC League of Super-Pets | Lex Luthor (voice) | |
| Movie | 2024 | The Order | Alan Berg | |
| Movie | 2012 | Sleepwalk with Me | Marc | |
| Movie | 1997 | Who's the Caboose? | Comedian | |
| Movie | N/A | Spenser Confidential 2 | Wayne Cosgrove | |
| Movie | 2005 | Left of the Dial | Self | |
| Movie | 1995 | HBO Comedy Half Hour: Marc Maron | | |
| Movie | 2013 | When Jews Were Funny | Himself | |
| Movie | 2002 | Stalker Guilt Syndrome | Stalker | |
| Movie | 2014 | Her: Love in the Modern Age | Self | |
| Movie | 2013 | All Wifed Out | Stan | |
| Movie | 2013 | Marc Maron: Thinky Pain | Himself | |
| Movie | 2022 | Maraschino Ruby | Snake (voice) | |
| Movie | 2023 | Genie | Lenny | |
| Movie | 2025 | The Bad Guys 2 | Snake (voice) | |
| Movie | 2015 | Misery Loves Comedy | Self | |
| Movie | 2016 | Ear Buds: The Podcasting Documentary | Self | |
| Movie | 2015 | Flock of Dudes | Richtman | |
| Movie | 2024 | Drew Friedman: Vermeer of the Borscht Belt | Self | |
| Movie | 2015 | Call Me Lucky | Self | |
| Movie | 2016 | Get a Job | Motel Manager | |
| Movie | 2012 | Alone Up There | Self | |
| Movie | 2015 | Marc Maron: More Later | Himself | |
| Movie | 2016 | Sidemen: Long Road To Glory | Narrator (voice) | |
| Movie | 2015 | Frank and Cindy | Gilbert | |
| Movie | 2016 | Mike and Dave Need Wedding Dates | Randy | |
| Movie | 2017 | Marc Maron: Too Real | Self | |
| Movie | 1999 | Los Enchiladas! | Devin | |
| Movie | 2015 | Sharknado 3: Oh Hell No! | Club Promoter (Uncredited) | |
| Movie | 2000 | Almost Famous | Angry Promoter | |
| Movie | 2012 | The Bitter Buddha | Self | |
| Movie | 2018 | Duck Butter | Marc (voice) | |
| Movie | 2019 | Joker | Gene Ufland | |
| Movie | 2002 | The N.Y. Friars Club Roast of Chevy Chase | Self - Roaster | |
| Movie | 2019 | Sword of Trust | Mel | |
| Movie | 2008 | A Bad Situationist | Mikel | |
| Movie | 2020 | Stardust | Ron Oberman | |
| Movie | 2020 | Spenser Confidential | Wayne Cosgrove | |
| Movie | 2021 | Respect | Jerry Wexler | |
| Movie | 2020 | Marc Maron: End Times Fun | | |
| Movie | 2020 | Feeding America Comedy Festival | Self | |
| Movie | 2014 | I Am Road Comic | Self | |
| Movie | 2020 | Her Effortless Brilliance: A Celebration of Lynn Shelton Through Film and Music | Self | |
| Movie | 2020 | Best of Stand-up 2020 | Self | |
| Movie | 2022 | The Bad Guys | Snake (voice) | |
| Movie | 2022 | To Leslie | Sweeney | |
| Movie | 2021 | Worth | Bart Cuthbert | |
| Movie | 2021 | Too Soon: Comedy After 9/11 | Self | |
| Movie | N/A | In Memoriam | Langston | |
| Movie | 2024 | Age of Audio | Self | |
| Movie | 2025 | Springsteen: Deliver Me from Nowhere | Chuck Plotkin | |
| Movie | 2012 | CC:Stand-Up: The Bonnaroo Experience | Self | |
| Movie | 2025 | The Bad Guys: Little Lies and Alibis | Snake (voice) | |
| Movie | 2025 | Are We Good? | Himself | |
| Movie | 2025 | Anxiety Club | Self | |
| Movie | 2025 | Marc Maron: Panicked | Self | |
| Movie | 2022 | Devise the Plan: Making 'The Bad Guys' | Self | |
| Movie | 2012 | Sensitive Man | Sensitivity Student | |
| Movie | N/A | The Bad Guys 3 | Snake (voice) | |
| TV Show | 1995 | Dr. Katz, Professional Therapist | Marc (voice) | 2 |
| TV Show | 2019 | Tamron Hall | Self - Guest | 1 |
| TV Show | 2012 | Finding Your Roots | Self | 1 |
| TV Show | 1998 | Comedy Central Presents | Self | 2 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 11 |
| TV Show | 2020 | The Comedy Store | Self | 5 |
| TV Show | 1996 | Good News Week | Self | 1 |
| TV Show | 2002 | Never Mind the Buzzcocks | Self - Host | 6 |
| TV Show | 2013 | Norm Macdonald Live | Self | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2022 | Dark Side of Comedy | Self | 2 |
| TV Show | 2013 | Maron | Marc Maron | 49 |
| TV Show | 2010 | The Green Room with Paul Provenza | Self | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 1 |
| TV Show | 2016 | Easy | Jacob Malco | 3 |
| TV Show | 2014 | Penn Zero: Part-Time Hero | Piv (voice) | 2 |
| TV Show | 2015 | Harvey Beaks | Randl (voice) | 98 |
| TV Show | 2023 | Adventure Time: Fionna & Cake | Squirrel (voice) | 2 |
| TV Show | 2023 | Adventure Time: Fionna & Cake | Additional Voices (voice) | 1 |
| TV Show | 2017 | The History of Comedy | Self | 14 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 4 |
| TV Show | 2017 | GLOW | Sam Sylvia | 30 |
| TV Show | 2015 | Close Up with The Hollywood Reporter | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2024 | After Midnight | Self | 1 |
| TV Show | 2021 | Reservation Dogs | Gene | 1 |
| TV Show | 2012 | The Burn with Jeff Ross | Self | 1 |
| TV Show | 2013 | The Jeselnik Offensive | Self | 1 |
| TV Show | 2025 | Stick | Mitts | 10 |
| TV Show | 2023 | Jam Van | Grumpy GPS (voice) | 8 |
| TV Show | 1989 | The Simpsons | Marc Maron (voice) | 1 |
| TV Show | 2010 | Adventure Time | Squirrel | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 2 |
| TV Show | 2010 | Conan | Self | 5 |
| TV Show | 2025 | Everybody's Live with John Mulaney | Self - Actor and Podcaster | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self | 1 |
| TV Show | 1996 | Full Frontal Comedy | self | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 1 |
| TV Show | 2020 | Who Wants to Be a Millionaire | Self - Contestant | 1 |
| TV Show | 2023 | Adventure Time: Fionna & Cake | Squirrel / Cheers Narrator (voice) | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self - Guest | 1 |
