| Movie | 2023 | The Slumber Party | Principal Petersen | |
| Movie | 2015 | Inside Out | Dream Director / Mom's Anger (voice) | |
| Movie | 2024 | Inside Out 2 | Mom's Anger (voice) | |
| Movie | 2019 | Wyrm | Tanya | |
| Movie | 2014 | Birdman or (The Unexpected Virtue of Ignorance) | Lady in Bar | |
| Movie | 2025 | Summer of 69 | Betty Spaghetti | |
| Movie | 2016 | Other People | Aunt Patti | |
| Movie | 2019 | Wine Country | Val | |
| Movie | 2013 | Anchorman 2: The Legend Continues | Crowd Member at Ice Rink | |
| Movie | 2020 | 30 Rock: A One-Time Special | Paula Hornberger | |
| Movie | 2015 | Riley's First Date? | Mom's Anger (voice) | |
| Movie | 2015 | Sisters | Dana | |
| Movie | 2016 | Brother Nature | Woman in Suit | |
| Movie | 2021 | Amidst the Chaos – Live (Again) from the Hollywood Bowl | Self | |
| Movie | 2024 | Will & Harper | Self | |
| Movie | 2026 | The Cat in the Hat | (voice) | |
| Movie | 2007 | Saturday Night Live in the '90s: Pop Culture Nation | Self | |
| Movie | 2010 | Saturday Night Live in the 2000s: Time and Again | Self | |
| Movie | N/A | Die Hart 2: Die Harter | Cynthia | |
| Movie | 2015 | Gentle and Soft: The Story of the Blue Jean Committee | Patti Skrowaczeski | |
| TV Show | 2018 | A.P. Bio | Helen Henry Demarcus | 37 |
| TV Show | 2013 | The Awesomes | Gadget Gal (voice) | 30 |
| TV Show | 2002 | The Colin Quinn Show | | 3 |
| TV Show | 2023 | Not Dead Yet | Marlena | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 9 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 3 |
| TV Show | 2005 | Made in Hollywood | Self | 1 |
| TV Show | 2012 | The Mindy Project | Evelyn | 1 |
| TV Show | 2006 | 30 Rock | Paula Hornberger | 6 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self - Guest | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2015 | Documentary Now! | Patty | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2021 | Monsters at Work | Sunny (voice) | 4 |
| TV Show | 2009 | Parks and Recreation | Tammy Zero | 1 |
| TV Show | 2017 | No Activity | Trucker | 1 |
| TV Show | 2017 | No Activity | Daisy | 1 |
| TV Show | 2020 | Mapleworth Murders | Abigail Mapleworth | 12 |
| TV Show | 2015 | Unbreakable Kimmy Schmidt | Bev | 1 |
| TV Show | 2017 | Big Mouth | Barbara Glouberman (voice) | 16 |
| TV Show | 2017 | Big Mouth | (voice) | 1 |
| TV Show | 2017 | Big Mouth | Barbara Glouberman / Bubbe (voice) | 1 |
| TV Show | 2017 | Big Mouth | Barbara Glouberman / Lola's Couch Pillow (voice) | 1 |
| TV Show | 1990 | Super Force | Mrs. BIloxi | 1 |
| TV Show | 2024 | Dream Productions | Paula Persimmon (voice) | 4 |
| TV Show | 2021 | Girls5eva | Gloria | 22 |
| TV Show | 2017 | Big Mouth | | 3 |
| TV Show | 2017 | Carpool Karaoke: The Series | Self | 1 |
| TV Show | 2020 | Die Hart | Cynthia | 4 |
| TV Show | 2026 | The 'Burbs | Dana Richards | 8 |
| TV Show | 2019 | Harley Quinn | G.A.I.L (voice) | 1 |
| TV Show | 2025 | Dying for Sex | Nurse Amy | 1 |
| TV Show | 2025 | Everybody's Live with John Mulaney | Jean Dumb | 1 |
| TV Show | 2022 | Loot | Paula | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self - Guest | 5 |
| TV Show | 2014 | Late Night with Seth Meyers | Trisha Bumrock | 1 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Robin Walker Fan (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Paula (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Self (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Mother (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Church Member (uncredited) | 2 |
| TV Show | 1975 | Saturday Night Live | Karen Coolidge (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Self / Taddli Audience Member (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Audience Member (uncredited) | 8 |
| TV Show | 1975 | Saturday Night Live | Caller (voice) (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Betty Michaels (uncredited) | 1 |
| TV Show | 1975 | Saturday Night Live | Betty Ford (voice) | 1 |
| TV Show | 1975 | Saturday Night Live | Laughing Writer (uncredited) | 1 |
