| Movie | 2014 | Infested! Living With Parasites | Self - Presenter | |
| Movie | 2009 | 10 Things You Need to Know About Losing Weight | Self - Presenter | |
| Movie | 2017 | Michael Mosley vs The Superbugs | Himself (Presenter) | |
| Movie | 2017 | 10 Things You Need to Know About the Future | Self | |
| Movie | 2020 | Addicted to Painkillers? Britain's Opioid Crisis | Self - Presenter | |
| Movie | 2013 | The Sarah Millican Television Programme - Best of Series 1-2 | Self | |
| Movie | 2011 | Pleasure and Pain with Michael Mosley | Host | |
| Movie | 2012 | Guts: The Strange and Mysterious World of the Human Stomach | Self | |
| Movie | 2024 | Michael Mosley: The Doctor Who Changed Britain | Self (archive footage) | |
| Movie | 2014 | Should I Eat Meat? The Big Health Dilemma | | |
| Movie | 2012 | The Truth About Exercise | Himself - Presenter | |
| Movie | 2016 | Inside Porton Down: Britain's Secret Weapons Research Facility | Himself - Presenter | |
| Movie | 2014 | Is Your Brain Male or Female? | Presenter | |
| Movie | 2013 | Winter Viruses and How to Beat Them | Himself - Presenter | |
| Movie | 2015 | The Wonderful World of Blood with Michael Mosley | Presenter | |
| Movie | 2012 | Eat, Fast and Live Longer | Self / Presenter / Journalist | |
| TV Show | 2006 | The One Show | Self | 23 |
| TV Show | 2021 | 21 Day Body Turnaround with Michael Mosley | Self | 3 |
| TV Show | 1964 | Horizon | Self - Presenter | 6 |
| TV Show | 1964 | Horizon | Narrator | 1 |
| TV Show | 2017 | Meet the Humans | Self - Host | 5 |
| TV Show | 2022 | Sunday with Laura Kuenssberg | Self – TV Presenter | 1 |
| TV Show | 2020 | Lose a Stone in 21 Days with Michael Mosley | Self - Presenter | 3 |
| TV Show | 2008 | Medical Mavericks | Self - Presenter | 4 |
| TV Show | 2011 | Michael Mosley's Science of You | Himself | 4 |
| TV Show | 2010 | The Story of Science: Power, Proof and Passion | Himself - Presenter | 6 |
| TV Show | 2023 | Secrets of the Superagers | Self | 6 |
| TV Show | 2013 | Trust Me, I'm a Doctor | Himself | 37 |
| TV Show | 1964 | Horizon | Self | 1 |
| TV Show | 2008 | Blood and Guts: A History of Surgery | Presenter | 5 |
| TV Show | 2013 | Pain, Pus and Poison: The Search for Modern Medicines | Self - Presenter | 3 |
| TV Show | 2013 | The Genius of Invention | Presenter | 4 |
| TV Show | 2011 | The Brain: A Secret History | Self - Presenter | 3 |
| TV Show | 2015 | Countdown to Life: The Extraordinary Making of You | Presenter | 3 |
| TV Show | 2017 | The Secrets of Your Food | Himself - Presenter | 3 |
| TV Show | 2011 | Inside the Human Body | Self - Presenter | 4 |
| TV Show | 2024 | Undercover Doctor: The Secrets of Your Big Shop | Self - Host | 1 |
| TV Show | 2019 | Dr Michael Mosley's Reset | Self | 3 |
| TV Show | 2024 | Michael Mosley: Secrets of Your Big Shop | Self - Host | 4 |
| TV Show | 2018 | Celebrities on the NHS Frontline | Self | 2 |
| TV Show | 2021 | Australia's Health Revolution with Dr Michael Mosley | Self | 3 |
| TV Show | 2024 | Australia's Sleep Revolution with Dr Michael Mosley | Self | 3 |
| TV Show | 2011 | Frontline Medicine | Self - Presenter | 2 |
| TV Show | 2020 | The Diagnosis Detectives | Self - Presenter | 4 |
| TV Show | 2024 | Michael Mosley - Just One Thing | Self - Presenter | 2 |
| TV Show | 2024 | Michael Mosley: Wonders of the Human Body | Self - Presenter | 3 |
