| Movie | 2023 | Rap Trap: Hip-Hop on Trial | Self | |
| Movie | 2022 | Adult Swim Festival Presents: Run the Jewels | Self | |
| Movie | 2001 | Jackboyz | | |
| Movie | 2021 | 2021 and Done with Snoop Dogg & Kevin Hart | Self | |
| Movie | 2020 | Run The Jewels "Yankee and the Brave (ep. 4)" | | |
| Movie | 2015 | Run the Jewels - Rock en Seine 2015 | Self | |
| Movie | 2013 | Criminal Behavior | Anthony | |
| Movie | 2023 | The Crossover: 50 Years of Hip Hop and Sports | Self | |
| Movie | 2017 | Black, White & Blue | Self | |
| Movie | 2023 | Big Bruh | Money Montez Sheffield / Montez Sr. (voice) | |
| Movie | 2024 | As We Speak: Rap Music on Trial | Self | |
| Movie | 2022 | Byron Bowers: Spiritual N***a | Self (uncredited) | |
| Movie | 2022 | Aqua Teen Forever: Plantasm | Boxy Brown (voice) | |
| Movie | 2024 | Freaknik: The Wildest Party Never Told | Self - Rapper/Activist | |
| Movie | 2006 | ATL | Killer Mike | |
| Movie | 2017 | Logic's Everybody Documentary | Self | |
| Movie | 2017 | Baby Driver | Restaurant Patron #2 | |
| Movie | 2017 | Word is Bond | Self | |
| Movie | 2019 | Grass Is Greener | Self | |
| Movie | 2016 | Hidden Colors 4: The Religion of White Supremacy | Himself | |
| Movie | 2012 | Question Bridge: Black Males | Himself | |
| Movie | 2020 | We Are George Floyd | Self | |
| Movie | 2020 | Holy Calamavote – A Special Performance by Run The Jewels | Self | |
| Movie | 2021 | Black Renaissance: The Art and Soul of Our Stories | Self | |
| Movie | 2021 | America: The Motion Picture | Blacksmith (voice) | |
| Movie | 2015 | Run the Jewels: [2015] Reading Festival | | |
| Movie | 2014 | Elementary Genocide | Himself | |
| Movie | 2025 | Everybody Wants to Be Gen X | Self | |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2006 | Frisky Dingo | Taqu'il (voice) | 25 |
| TV Show | 2020 | DAVE | Killer Mike | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Musical Guest | 1 |
| TV Show | 2022 | The Game Plan with Shaquille O'Neal | Self | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2023 | Celebrity Prank Wars | Self | 1 |
| TV Show | 2021 | Chillin Island | Self | 1 |
| TV Show | 2012 | The Eric Andre Show | Self | 2 |
| TV Show | 2016 | Billions | Killer Mike | 1 |
| TV Show | 2011 | Portlandia | Killer Mike | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 2 |
| TV Show | 2016 | Party Legends | | 1 |
| TV Show | 2017 | Ozark | Killer Mike | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 1 |
| TV Show | 2019 | Trigger Warning with Killer Mike | Self | 6 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self - Musical Guest | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 7 |
| TV Show | 2023 | Fight the Power: How Hip Hop Changed the World | Self | 4 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 3 |
| TV Show | 2019 | Momma Named Me Sheriff | Dr. Um Actually (voice) | 1 |
| TV Show | 2021 | Love & Respect with Killer Mike | Self - Host | 21 |
| TV Show | 2019 | Desus & Mero | Self - Illustrious Guest | 1 |
| TV Show | 2001 | BET Awards | Self | 1 |
| TV Show | 2000 | Aqua Teen Hunger Force | Boost Mobile Phone (voice) | 1 |
| TV Show | 2025 | The Lowdown | Cyrus | 2 |
