| Movie | 2008 | The Rocker | Robert 'Fish' Fishman | |
| Movie | 2005 | The Life Coach | Dr. Watson Newmark | |
| Movie | 2000 | Almost Famous | David Felton | |
| Movie | 2007 | The Last Mimzy | Larry White | |
| Movie | 2003 | House of 1000 Corpses | Bill Hudley | |
| Movie | 2006 | My Super Ex-Girlfriend | Vaughn Haige | |
| Movie | 2021 | Three Short Plays by Tracy Letts | Gary | |
| Movie | 2007 | Juno | Rollo | |
| Movie | 2005 | Sahara | Rudi Gunn | |
| Movie | 2001 | America's Sweethearts | Dave O'Hanlon | |
| Movie | 2009 | Transformers: Revenge of the Fallen | Professor Colan | |
| Movie | 2009 | Monsters vs Aliens | Gallaxhar (voice) | |
| Movie | 2011 | Fight for Your Right Revisited | Church Goer | |
| Movie | 2010 | Hesher | Paul Forney | |
| Movie | 2010 | Super | Frank Darbo | |
| Movie | 2001 | When Billie Beat Bobby | Dennis Van De Meer | |
| Movie | 2009 | Mutant Pumpkins from Outer Space | Wicked Jack (voice) | |
| Movie | 2010 | Peep World | Joel | |
| Movie | 2022 | Weird: The Al Yankovic Story | Dr. Demento | |
| Movie | 2005 | Wheelmen | Barny | |
| Movie | 2015 | Uncanny | Castle | |
| Movie | 2013 | The Stream | Adult Ernest | |
| Movie | 2014 | Cooties | Wade | |
| Movie | 2015 | The Boy | William Colby | |
| Movie | 2024 | Code 3 | Randy | |
| Movie | 2018 | The Meg | Morris | |
| Movie | 1999 | Galaxy Quest | Lahnk | |
| Movie | 2024 | Ezra | Nick | |
| Movie | 2024 | Empire Waist | Mark Miller | |
| Movie | 2016 | Army of One | Agent Simons | |
| Movie | 2004 | Baadasssss! | Bill Harris | |
| Movie | 2024 | ILY, BYE | Mr. Litchfield | |
| Movie | N/A | At the Sea | | |
| Movie | 2024 | Home Delivery | Cheyenne | |
| Movie | 2024 | Hollywood's Humble Maestro: The Russell Garcia Story | Narrator | |
| Movie | 2017 | Smurfs: The Lost Village | Gargamel (voice) | |
| Movie | 2017 | Permanent | Jim Dixon | |
| Movie | 2017 | Shimmer Lake | Andy Sikes | |
| Movie | 2017 | Thom Pain | Thom Pain | |
| Movie | 2013 | Monsters vs Aliens Stories | | |
| Movie | 2019 | Reign of the Supermen | Lex Luthor (voice) | |
| Movie | 2018 | The Death of Superman | Lex Luthor (voice) | |
| Movie | 2018 | The Gate: Dawn of the Bahá’í Faith | Himself | |
| Movie | 2019 | Blackbird | Michael | |
| Movie | 2020 | Don't Tell a Soul | Mr. Hamby / Randy Michael Sadler | |
| Movie | 2024 | MURDER and murder | George | |
| Movie | 2019 | Where In The Hell Is The Lavender House: The Longmont Potion Castle Story | Self | |
| Movie | 2019 | Batman: Hush | Lex Luthor (voice) | |
| Movie | 2019 | The Death and Return of Superman | Lex Luthor (voice) | |
| Movie | 2019 | Laughing Matters | Self | |
| Movie | 2010 | Still on the Road | Self | |
| Movie | 2019 | Never Surrender: A Galaxy Quest Documentary | Self | |
| Movie | 2020 | Justice League Dark: Apokolips War | Lex Luthor (voice) | |
| Movie | 2019 | Transparent: Musicale Finale | Arthur | |
| Movie | 2013 | The Office Retrospective | Self | |
| Movie | 2002 | Full Frontal | First Fired Employee | |
| Movie | 2013 | Here Comes the Night Time | Carl the Roadie | |
| Movie | 2024 | Hitpig! | Leapin' Lord of the Leotard (voice) | |
| Movie | 2020 | Don't Look Back | George Reed | |
| Movie | 2005 | Six Feet Under: In Memoriam | Himself | |
| Movie | 2008 | VH1 Rock Honors: The Who | Self | |
| Movie | 2014 | Good Samaritan | George Reed | |
| Movie | 2021 | Dan Mangan is the Least Cool Thing | Self | |
| Movie | 2022 | Jerry & Marge Go Large | Bill | |
| Movie | 2012 | The Office: Secret Santa Pack | Dwight Schrute | |
| Movie | 2025 | Deepfaking Sam Altman | Self | |
| TV Show | 2001 | Six Feet Under | Arthur Martin | 13 |
| TV Show | 2000 | CSI: Crime Scene Investigation | Guy in Supermarket | 1 |
| TV Show | 1999 | Family Guy | Dwight Schrute (voice) | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | | 1 |
| TV Show | 2002 | Monk | | 0 |
| TV Show | 1952 | Today | Self | 1 |
| TV Show | 2005 | The Office | Dwight Schrute | 186 |
| TV Show | 2004 | Entourage | | 1 |
| TV Show | 1998 | Charmed | Kierkan | 1 |
| TV Show | 2017 | Room 104 | Jim | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Mr. Baltzer | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 4 |
| TV Show | 2009 | The Jay Leno Show | Self | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 3 |
| TV Show | 2014 | Running Wild with Bear Grylls | Self | 1 |
| TV Show | 2012 | Good Mythical Morning | Self | 1 |
| TV Show | 2006 | VH1 Rock Honors | | 1 |
| TV Show | 2021 | The Choe Show | Self | 2 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2023 | Rainn Wilson and the Geography of Bliss | Self - Host | 5 |
| TV Show | 2018 | Explained | Narrator (voice) | 1 |
| TV Show | 2015 | Backstrom | Det. Lt. Backstrom | 13 |
| TV Show | 2018 | The Rookie | Rainn Wilson | 1 |
| TV Show | 2000 | Dark Angel | Phil | 1 |
| TV Show | 2022 | StoryBots: Answer Time | | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self | 1 |
| TV Show | 2002 | Monk | Walker Browning | 1 |
| TV Show | 1992 | MTV Movie & TV Awards | Self - Presenter | 1 |
| TV Show | 2021 | The Center Seat: 55 Years of Star Trek | Self | 1 |
| TV Show | 2014 | Transparent | Arthur | 1 |
| TV Show | 2023 | Lessons in Chemistry | Phil Lebensmal | 4 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Cinco Spokesman | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Video Match Client | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Blind Man | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Bobby Stoan | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Bobby Stoan (uncredited) | 1 |
| TV Show | 2020 | Home Movie: The Princess Bride | Vizzini | 1 |
| TV Show | 2017 | Star Trek: Discovery | Harry Mudd | 2 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 2 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2013 | Acting Disruptive | Self | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 2 |
| TV Show | 2019 | UnMade | Himself | 1 |
| TV Show | 2018 | Star Trek: Short Treks | Harry Mudd | 1 |
| TV Show | 2020 | Utopia | Michael Stearns | 8 |
| TV Show | 2002 | MDs | John Doe | 2 |
| TV Show | 2019 | A Little Late with Lilly Singh | Self | 3 |
| TV Show | 2020 | Some Good News | Self | 2 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 1 |
| TV Show | 2013 | Mom | Trevor | 9 |
| TV Show | 2020 | We Are the Champions | Narrator | 6 |
| TV Show | 2010 | Conan | Self | 1 |
| TV Show | 2020 | Celebrity IOU | Self | 1 |
| TV Show | 2006 | The Megan Mullally Show | Self - Guest | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2022 | Dark Winds | Dan 'Devoted Dan' DeMarco | 3 |
| TV Show | 2021 | Celebrity Wheel of Fortune | Self - Contestant | 1 |
| TV Show | 2021 | Last Meals | | 1 |
| TV Show | 2020 | Solar Opposites | Steven (voice) | 2 |
| TV Show | 2005 | Numb3rs | Martin Grolsch | 1 |
| TV Show | 2003 | DreamWorks 6 Spooky Stories Collection | Wicked Jack (voice) | 1 |
