| Movie | 2006 | Brother Bear 2 | Kata (voice) | |
| Movie | 1990 | Home Alone | Kate | |
| Movie | 1992 | Home Alone 2: Lost in New York | Kate | |
| Movie | 1988 | Beetlejuice | Delia | |
| Movie | 1985 | After Hours | Gail | |
| Movie | 1983 | Rock & Rule | Aunt Edith (voice) | |
| Movie | 2006 | Over the Hedge | Penny (voice) | |
| Movie | 2006 | Penelope | Jessica Wilhern | |
| Movie | 1980 | From Cleveland | Various | |
| Movie | 1994 | Wyatt Earp | Allie Earp | |
| Movie | 1985 | PMS - Premenstrual Syndrome | Mary Marcus | |
| Movie | 1998 | Home Fries | Beatrice Lever | |
| Movie | 1994 | The Paper | Susan | |
| Movie | 1993 | The Nightmare Before Christmas | Sally / Shock (voice) | |
| Movie | 2010 | Temple Grandin | Aunt Ann | |
| Movie | 2006 | Monster House | Mom (voice) | |
| Movie | 2003 | The Rutles 2: Can't Buy Me Lunch | Astro Glide | |
| Movie | 1997 | Pippi Longstocking | Mrs. Helga Prysselius (voice) | |
| Movie | 2021 | Back Home Again | Mayor Owl (voice) | |
| Movie | 2005 | Chicken Little | Tina - Alien Mom (voice) | |
| Movie | 2003 | A Mighty Wind | Mickey Crabbe | |
| Movie | 1986 | Heartburn | Betty | |
| Movie | 2000 | Best in Show | Cookie Fleck | |
| Movie | 2021 | An Audience with Adele | Self | |
| Movie | 2023 | Elemental | Brook (voice) | |
| Movie | 2006 | For Your Consideration | Marilyn Hack | |
| Movie | 1994 | A Simple Twist of Fate | April Simon | |
| Movie | 2004 | Surviving Christmas | Christine Valco | |
| Movie | 2010 | Killers | Mrs. Kornfeldt | |
| Movie | 2012 | Frankenweenie | Mrs. Frankenstein / Weird Girl / Gym Teacher (voice) | |
| Movie | 1996 | The Last of the High Kings | Cathleen | |
| Movie | 1996 | Waiting for Guffman | Sheila Albertson | |
| Movie | 2009 | Where the Wild Things Are | Judith (voice) | |
| Movie | 1978 | Witch's Night Out | Malicious | |
| Movie | 1999 | Bartok the Magnificent | Ludmilla (voice) | |
| Movie | 2009 | Away We Go | Gloria Farlander | |
| Movie | 2024 | Beetlejuice Beetlejuice | Delia | |
| Movie | 2021 | Catherine O'Hara: All of Us Shine | Self | |
| Movie | 1985 | The Last Polka | Lemon Twin | |
| Movie | 2013 | A.C.O.D. | Melissa | |
| Movie | 2013 | The Right Kind of Wrong | Tess | |
| Movie | 1999 | Late Last Night | Dr. Fontes | |
| Movie | 2013 | Tales from the Warner Bros. Lot | Self | |
| Movie | 1979 | Intergalactic Thanksgiving, or Please Don't Eat the Planet | Ma Spademinder (voice) | |
| Movie | 2002 | Orange County | Cindy Beugler | |
| Movie | 1999 | The Life Before This | Sheena | |
| Movie | 2023 | Pain Hustlers | Jackie | |
| Movie | 1990 | Little Vegas | Lexie | |
| Movie | 1992 | There Goes the Neighborhood | Jessie Lodge | |
| Movie | 2005 | Wild About Books | | |
| Movie | 2020 | Canada Far and Wide | Herself | |
| Movie | 1995 | Tall Tale: The Unbelievable Adventure | Calamity Jane | |
| Movie | 1997 | Hope | Muriel Macswain | |
| Movie | 2024 | The Wild Robot | Pinktail (voice) | |
| Movie | 2015 | Being Canadian | Self | |
| Movie | 1980 | Easter Fever | Scarlett O'Hare (voice) | |
| Movie | 2006 | Christmas with SCTV | | |
| Movie | 1980 | Double Negative | Judith | |
| Movie | 2000 | Edwurd Fudwupper Fibbed Big | Lorna Mae Loon (voice) | |
| Movie | 1986 | Really Weird Tales | Theresa Sharpe (segment "I'll Die Loving") | |
| Movie | 2004 | Lemony Snicket's A Series of Unfortunate Events | Justice Strauss | |
| Movie | 2004 | The Wool Cap | Gloria | |
| Movie | 2006 | Game 6 | Lillian Rogan | |
| Movie | 1986 | The Incredible Time-Travels of Henry Osgood | Marie Antoinette | |
| Movie | N/A | Twilight Park | Queen Henrietta | |
| Movie | 1980 | Nothing Personal | Audrey | |
| Movie | 2001 | Speaking of Sex | Connie Barker | |
| Movie | 1990 | Dick Tracy | Texie Garcia | |
| Movie | 1985 | Tears Are Not Enough | Self | |
| Movie | 2006 | Barbie in the 12 Dancing Princesses | Duchess Rowena (voice) | |
| Movie | 1990 | Betsy's Wedding | Gloria Henner | |
| Movie | 2019 | The Addams Family | Grandma Frump (voice) | |
| Movie | 2021 | Extinct | Alma (voice) | |
| Movie | 2005 | John Candy: Comic Spirit | Self | |
| Movie | 2020 | Best Wishes, Warmest Regards: A Schitt's Creek Farewell | Self | |
| Movie | 2020 | Stronger Together, Tous Ensemble | Self | |
| Movie | 1988 | The Best of SCTV | | |
| Movie | 1989 | I, Martin Short, Goes Hollywood | Nancy Mae | |
| Movie | 1982 | Rome, Italian Style | Ursula Schneider | |
| Movie | 2002 | Searching for Debra Winger | Self | |
| Movie | 1989 | Andrea Martin... Together Again | | |
| Movie | 2021 | The Last Kids on Earth: Happy Apocalypse to You | | |
| Movie | 2024 | Argylle | Ruth | |
| Movie | 2025 | You Had to Be There: How the Toronto Godspell Ignited the Comedy Revolution... | | |
| Movie | 1991 | Rabbit Ears - Finn McCoul | Narrator (voice) | |
| TV Show | 2001 | Six Feet Under | Carol Ward | 4 |
| TV Show | 1985 | George Burns Comedy Week | | 13 |
| TV Show | 1990 | Dream On | Irma | 1 |
| TV Show | 1989 | Tales from the Crypt | Geraldine Ferrett (segment "Let the Punishment Fit the Crime") | 1 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 2 |
| TV Show | 1976 | Second City Television | Self - Various Characters | 80 |
| TV Show | 2016 | Full Frontal with Samantha Bee | Self | 1 |
| TV Show | 2012 | Inside Comedy | Self | 1 |
| TV Show | 2012 | The Greatest Event in Television History | Muriel Rush | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee | 1 |
| TV Show | 1995 | MADtv | Woman on Blind Date | 1 |
| TV Show | 2009 | Modern Family | Dr. Debra Radcliffe | 1 |
| TV Show | 1990 | The Dave Thomas Comedy Show | | 5 |
| TV Show | 1997 | Pippi Longstocking | | 0 |
| TV Show | 1991 | The Hidden Room | Laurel Brody | 33 |
| TV Show | 1984 | The New Show | | 10 |
| TV Show | 1983 | SCTV Channel | | 19 |
| TV Show | 2009 | Glenn Martin, DDS | Jackie Martin | 40 |
| TV Show | 1991 | Morton & Hayes | Amelia Von Astor | 6 |
| TV Show | 1995 | The Outer Limits | Becka Paulson | 1 |
| TV Show | 1988 | The Completely Mental Misadventures of Ed Grimley | Miss Malone | 13 |
| TV Show | 1953 | The Oscars | Self | 2 |
| TV Show | 1992 | The Larry Sanders Show | Catherine O'Hara | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 2 |
| TV Show | 2001 | Committed | | 13 |
| TV Show | 2015 | Schitt's Creek | Moira Rose | 79 |
| TV Show | 2015 | What Lives Inside | Sarah Delaney | 4 |
| TV Show | 2015 | Moonbeam City | Glam (voice) | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | Bam Bam | 1 |
| TV Show | 2006 | 30 Rock | Pearline | 1 |
| TV Show | 1998 | Oh Baby | | 1 |
| TV Show | 2017 | A Series of Unfortunate Events | Dr. Orwell | 3 |
| TV Show | 2006 | Second City: First Family of Comedy | Self (Archival Footage) | 3 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 4 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 1 |
| TV Show | 2014 | PaparaGilles | Self | 1 |
| TV Show | 2025 | The Studio | Patty Leigh | 10 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 1 |
| TV Show | 2020 | Stars in the House | Self | 1 |
| TV Show | 2019 | The Last Kids on Earth | Skaelka (voice) | 21 |
| TV Show | 2020 | Who Wants to Be a Millionaire | Self - Contestant | 2 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self | 1 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 1988 | Whose Line Is It Anyway? | Herself | 3 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 1 |
| TV Show | 1995 | Dr. Katz, Professional Therapist | Catherine (voice) | 1 |
| TV Show | 2002 | Bram & Alice | Ms. O'Connor | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Presenter | 1 |
| TV Show | 2023 | The Last of Us | Gail | 3 |
