| Movie | 2000 | Snatch | Franky Four Fingers | |
| Movie | 2005 | Sin City | Jackie Boy | |
| Movie | 2003 | 21 Grams | Jack Jordan | |
| Movie | 1996 | Basquiat | Benny Dalmau | |
| Movie | 1995 | The Usual Suspects | Fenster | |
| Movie | 1989 | Licence to Kill | Dario | |
| Movie | 2000 | The Way of the Gun | Mr. Longbaugh | |
| Movie | 1998 | Fear and Loathing in Las Vegas | Dr. Gonzo | |
| Movie | 2000 | Traffic | Javier Rodriguez | |
| Movie | 2003 | The Hunted | Aaron Hallam | |
| Movie | 2007 | Things We Lost in the Fire | Jerry Sunborne | |
| Movie | 1993 | Fearless | Manny Rodrigo | |
| Movie | 1994 | Swimming with Sharks | Rex | |
| Movie | 2015 | The Poet of Havana | Self | |
| Movie | 2001 | The Pledge | Toby Jay Wadenah | |
| Movie | 1988 | Big Top Pee-wee | Duke the Dog-Faced Boy | |
| Movie | 1996 | The Funeral | Gaspare | |
| Movie | 2010 | The Wolfman | Lawrence Talbot | |
| Movie | 2008 | Che: Part Two | Ernesto Che Guevara | |
| Movie | 2008 | Che: Part One | Ernesto Che Guevara | |
| Movie | 1991 | The Indian Runner | Miguel | |
| Movie | 1994 | China Moon | Lamar Dickey | |
| Movie | 2006 | Buy the Ticket, Take the Ride | Self | |
| Movie | 1996 | The Fan | Juan Primo | |
| Movie | 1997 | Excess Baggage | Vincent | |
| Movie | 2004 | 21 Grams: In Fragments | Self | |
| Movie | 2010 | Making Che | Self | |
| Movie | 1992 | Christopher Columbus: The Discovery | Alvaro Harana | |
| Movie | 2003 | Breakfast with Hunter | Self | |
| Movie | 1993 | Golden Balls | Bob, el amigo de Miami | |
| Movie | 2012 | Savages | Lado | |
| Movie | 1993 | Money for Nothing | Dino Palladino | |
| Movie | 2013 | Thor: The Dark World | Taneleer Tivan / The Collector (uncredited) | |
| Movie | 2025 | Teofilo: Boxing's Most Revolutionary Champion | Narrator | |
| Movie | 2014 | Guardians of the Galaxy | The Collector | |
| Movie | 2000 | Inside Traffic: The Making of 'Traffic' | Self | |
| Movie | 2013 | Jimmy P. | Jimmy Picard | |
| Movie | 2014 | Inherent Vice | Sauncho Smilax, Esq. | |
| Movie | 2004 | Sam Peckinpah's West: Legacy of a Hollywood Renegade | Self | |
| Movie | 2014 | Escobar: Paradise Lost | Pablo Escobar | |
| Movie | 2015 | Sicario | Alejandro Gillick | |
| Movie | 2003 | Filming “The Hunted” | Self | |
| Movie | 2003 | Pursuing “The Hunted” | Self | |
| Movie | 2003 | The Cutting Edge | Self | |
| Movie | 2005 | Trailer for a Remake of Gore Vidal's Caligula | Macro | |
| Movie | 2015 | A Perfect Day | Mambrú | |
| Movie | 1997 | Joyride | Detective Lopez | |
| Movie | 2022 | Bonnie | Self | |
| Movie | 2002 | Bond Girls Are Forever | Dario (archive footage) (uncredited) | |
| Movie | 2001 | Making 'Snatch' | Self | |
| Movie | 1997 | Cannes Man | Self | |
| Movie | 2017 | Star Wars: The Last Jedi | DJ | |
| Movie | 2010 | Somewhere | Celebrity (uncredited) | |
| Movie | 2008 | Shine a Light | Self - Concert Audience (uncredited) | |
| Movie | 2000 | Bread and Roses | Party Guest (uncredited) | |
| Movie | 2002 | The Bronze Screen: 100 Years of the Latino Image in American Cinema | Himself | |
| Movie | 2003 | Declaration of Independence | Self | |
| Movie | 2008 | The Upsetter: The Life and Music of Lee Scratch Perry | Narrator (voice) | |
| Movie | 2010 | The Rolling Stones: Stones in Exile | Self | |
| Movie | 2002 | Julia, toda en mí | | |
| Movie | 2025 | One Battle After Another | Sensei Sergio | |
| Movie | 2018 | Sicario: Day of the Soldado | Alejandro Gillick | |
| Movie | 2015 | Take Flight | Self - Performer | |
| Movie | 2015 | The Little Prince | The Snake (voice) | |
| Movie | 2003 | Hunter Goes to Hollywood | Self | |
| Movie | 2018 | Avengers: Infinity War | The Collector | |
| Movie | 2014 | Guide to the Galaxy with James Gunn | Self | |
| Movie | 2018 | The Director and the Jedi | Self | |
| Movie | N/A | All-Star Weekend | Dr. Phill | |
| Movie | 2019 | Dora and the Lost City of Gold | Swiper (voice) | |
| Movie | 2021 | The French Dispatch | Moses Rosenthaler | |
| Movie | N/A | The Corporation | Jose Miguel Battle Sr. | |
| Movie | 1998 | Spotlight on Location: Fear and Loathing in Las Vegas | Self | |
| Movie | 2002 | Round Up: Deposing 'The Usual Suspects' | Self | |
| Movie | 2002 | Keyser Soze, Lie or Legend - Featurette | Self | |
| Movie | 2004 | Creature Feature: 50 Years of the Gill-Man | Self | |
| Movie | 2021 | No Sudden Move | Ronald Russo | |
| Movie | 2019 | Other Music | Self | |
| Movie | 2000 | Inside 'Licence to Kill' | Self | |
| Movie | 1990 | Madonna: The Immaculate Collection | Kid Sitting on Car (segment "La Isla Bonita") | |
| Movie | 2019 | Raúl Juliá: The World’s a Stage | Self | |
| Movie | 2023 | Reptile | Tom Nichols | |
| Movie | 2019 | Nice Girls Don't Stay for Breakfast | Self - Actor | |
| Movie | N/A | Elysian Park and the Stone Quarry Hills | | |
| Movie | 2025 | The Phoenician Scheme | Zsa-zsa Korda | |
| TV Show | 1994 | Inside the Actors Studio | Self | 1 |
| TV Show | 2001 | Friday Night with Jonathan Ross | Self - Guest | 1 |
| TV Show | 1984 | Miami Vice | Pito | 1 |
| TV Show | 1989 | Tales from the Crypt | Bill | 1 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 2002 | Icons | | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 2 |
| TV Show | 1953 | The Oscars | Self | 2 |
| TV Show | 2021 | What If...? | The Collector (voice) | 1 |
| TV Show | 2018 | Escape at Dannemora | Richard Matt | 7 |
| TV Show | 1990 | Drug Wars: The Camarena Story | Caro Quintero | 3 |
| TV Show | 1993 | Fallen Angels | Paco | 1 |
| TV Show | 2015 | Close Up with The Hollywood Reporter | Self | 1 |
| TV Show | 2014 | Variety Studio: Actors on Actors | Self | 2 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 1 |
| TV Show | 2008 | Todos Contra Juan | Benicio del Toro | 1 |
