| Movie | 2006 | Cars | Ramone (voice) | |
| Movie | 2003 | Once Upon a Time in Mexico | Belini | |
| Movie | 2000 | Luminarias | | |
| Movie | 1996 | From Dusk Till Dawn | Border Guard / Chet Pussy / Carlos | |
| Movie | 2001 | Spy Kids | Felix Gumm | |
| Movie | 2024 | The Long Game | Pollo | |
| Movie | 1996 | Tin Cup | Romeo Posar | |
| Movie | 1985 | After Hours | Neil | |
| Movie | 1981 | Nice Dreams | Cheech | |
| Movie | 1982 | Things Are Tough All Over | Cheech / Mr. Slyman | |
| Movie | 1982 | It Came from Hollywood | Himself | |
| Movie | 2003 | Good Boy! | The Greater Dane's Henchman (voice) | |
| Movie | 2004 | The Lion King 1½ | Banzai (voice) | |
| Movie | 1978 | Up in Smoke | Pedro | |
| Movie | 1983 | Yellowbeard | El Segundo | |
| Movie | 1989 | Rude Awakening | Jesús Monteya | |
| Movie | 1985 | Get Out of My Room | Cheech | |
| Movie | 1995 | Desperado | Short Bartender | |
| Movie | 2010 | Machete | Padre Cortez | |
| Movie | 2003 | Masked and Anonymous | Prospero | |
| Movie | 1999 | Chato's Kitchen | | |
| Movie | 1994 | The Lion King | Banzai (voice) | |
| Movie | 1990 | Far Out Man | Himself | |
| Movie | 1988 | Oliver & Company | Tito (voice) | |
| Movie | 2003 | Spy Kids 3-D: Game Over | Felix Gumm | |
| Movie | 2002 | Spy Kids 2: The Island of Lost Dreams | Felix Gumm | |
| Movie | 1992 | FernGully: The Last Rainforest | Stump (voice) | |
| Movie | 2002 | The Original Latin Kings of Comedy | Himself | |
| Movie | 1983 | Still Smokin | Cheech | |
| Movie | 1990 | The Shrimp on the Barbie | Carlos | |
| Movie | 1980 | Cheech & Chong's Next Movie | Cheech / Dwayne "Red" Mendoza | |
| Movie | 2004 | Christmas with the Kranks | Officer Salino | |
| Movie | 2009 | Race to Witch Mountain | Eddie | |
| Movie | 2008 | Cheech & Chong Roasted | Self | |
| Movie | 2006 | Mater and the Ghostlight | Ramone (voice) | |
| Movie | 2010 | Cheech & Chong's Hey Watch This | Self | |
| Movie | 1998 | Paulie | Ignacio | |
| Movie | 2007 | Uncle P | Juan | |
| Movie | 2021 | Nash Bridges | Joe Dominguez | |
| Movie | 1984 | Cheech & Chong's The Corsican Brothers | Corsican Brother | |
| Movie | 2006 | AKA Tommy Chong | Himself | |
| Movie | 2025 | Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip | Gil Morales | |
| Movie | 2011 | Cars 2 | Ramone (voice) | |
| Movie | N/A | Naya: Legend of the Golden Dolphin | Dude (voice) | |
| Movie | 2005 | Underclassman | Captain Victor Delgado | |
| Movie | 1987 | Born in East L.A. | Rudy | |
| Movie | 2023 | Champions | Julio | |
| Movie | 2006 | Dizzy & Bop's Big Adventure: The Great Music Caper | Dr. Hammer (voice) | |
| Movie | 2009 | The Perfect Game | Padre Estaban | |
| Movie | 2010 | Pure Country 2: The Gift | Angel Pedro | |
| Movie | 2004 | Timon & Pumbaa's Virtual Safari 1.5 | Banzai (voice) (archive sound) | |
| Movie | 1989 | Ghostbusters II | Dock Supervisor | |
| Movie | 1998 | Breakfast with Einstein | Einstein (voice) | |
| Movie | 1974 | Basketball Jones | | |
| Movie | 1994 | The Magic of the Golden Bear: Goldy III | Master Borgia | |
| Movie | 1995 | Charlie's Ghost Story | Coronado | |
| Movie | 1983 | Return Engagement | Self | |
| Movie | 2006 | Cheech Marin & Friends: Live from South Beach | Self - Host | |
| Movie | 2007 | Bloodsucking Cinema | Self | |
| Movie | 2021 | Classic Albums: Frank Zappa & The Mothers Of Invention - Freak Out! | Self | |
| Movie | 1999 | The Nuttiest Nutcracker | Mac (Voice) | |
| Movie | 1994 | The Cisco Kid | Pancho | |
| Movie | 1995 | The Courtyard | Angel Steiner | |
| Movie | 2014 | The Book of Life | Pancho Rodriguez (voice) | |
| Movie | 2021 | A Song for Cesar: Beware a Movement That Sings | Self | |
| Movie | 2009 | Waking Sleeping Beauty | Tito (voice) (archive footage) | |
| Movie | 2016 | Americano | Martin (voice) | |
| Movie | 2000 | Picking Up the Pieces | Mayor Machado | |
| Movie | 2022 | Cypress Hill: Insane in the Brain | Self | |
| Movie | 1996 | The Great White Hype | Julio Escobar | |
| Movie | 2012 | George Lopez: It's Not Me, It's You | Self | |
| Movie | 1985 | Echo Park | Syd | |
| Movie | 2004 | See You in My Dreams | Esteban | |
| Movie | 2022 | Biography: The Bella Twins | Self (archival footage) | |
| Movie | 1991 | La Pastorela: The Shepherd's Tale | El Cosmico | |
| Movie | 2022 | Angry Neighbors | Hector (voice) | |
| Movie | 2009 | Expecting a Miracle | Father Arturo | |
| Movie | 2003 | Chavez Ravine: A Los Angeles Story | Narrator | |
| Movie | 2006 | Cars Wal-Mart Exclusive Geared UP | | |
| Movie | 2011 | Hoodwinked Too! Hood VS. Evil | Mad Hog (voice) | |
| Movie | 2015 | The Latin Explosion: A New America | Self | |
| Movie | 2013 | Cheech & Chong's Animated Movie! | (voices) | |
| Movie | 2017 | Cars 3 | Ramone (voice) | |
| Movie | 1984 | Elvira's MTV Halloween Party | | |
| Movie | 2007 | Grindhouse | Padre (segment "Planet Terror") | |
| Movie | 1988 | Mickey's 60th Birthday | Disneyland Janitor | |
| Movie | 1995 | 'Twas the Night Before Bumpy | Juaquin Gusanito Sin Manos (voice) | |
| Movie | 2020 | The War with Grandpa | Danny | |
| Movie | 1999 | The Venice Project | Cheech Marin | |
| Movie | 2017 | Coco | Corrections Officer (voice) | |
| Movie | 2014 | The Radiator Springs 500½ | Ramone (voice) | |
| Movie | 2016 | Dark Harvest | Ricardo | |
| Movie | 2013 | Spinning | Ramone (voice) | |
| Movie | 2008 | Beverly Hills Chihuahua | Manuel (voice) | |
| Movie | 2007 | Planet Terror | Priest | |
| Movie | 1983 | Group Madness | Self | |
| Movie | 1987 | Fatal Beauty | Bartender | |
| Movie | 1990 | Mother Goose Rock 'n' Rhyme | Carnival Barker | |
| Movie | 2019 | Inmate #1: The Rise of Danny Trejo | Self | |
| Movie | 2001 | Laughing Out Loud: America's Funniest Comedians | Self (archive footage) | |
| Movie | 1989 | Troop Beverly Hills | Cheech Marin | |
| Movie | 2020 | AGFA Mystery Mixtape #4: Follow Your Own Star | Self | |
| Movie | 1984 | Cannonball Run II | Tire Store Employee (uncredited) | |
| Movie | 2019 | Carlos Almaraz: Playing with Fire | Self | |
| Movie | 2016 | Good Fortune | Self | |
| Movie | 2022 | Shotgun Wedding | Robert Rivera | |
| Movie | 1994 | A Million to Juan | Shell Shock | |
| Movie | 2012 | El Santos vs la Tetona Mendoza | Narrador / El Charro (voice) | |
| Movie | 2003 | This So-Called Disaster | Esteban | |
| Movie | 1986 | Charlie Barnett's Terms of Enrollment | Elvis Friend & Fan | |
| Movie | 2003 | Tracey Ullman in the Trailer Tales | Himself | |
| Movie | 2021 | Quentin Tarantino: From a Movie Buff to a Hollywood Legend | Self (archive footage) | |
| Movie | 2017 | Elena of Avalor: Realm of the Jaquins | Quita Moz (voice) | |
| Movie | 1999 | Grass | Self (archive footage) | |
| Movie | 2003 | The Brothers Garcia: Mysteries of the Maya | Don Cortez | |
| Movie | 2025 | Cheech & Chong's Last Movie | Self | |
| Movie | 2020 | The AGFA Mystery Mixtape Vault | (archive footage) | |
| Movie | 1978 | Cheech and Chong Perform | Himself | |
| Movie | 1978 | Cheech and Chong Perform Again?! | Himself | |
| Movie | 2009 | Pixar Short Films | Ramone (voice) | |
| Movie | 1998 | It's Tough to be a Bug | Chili | |
| TV Show | 1996 | Nash Bridges | Joe Dominguez | 122 |
| TV Show | 1989 | The Simpsons | Cheech Marin (voice) | 1 |
| TV Show | 1999 | Judging Amy | Ignacio Messina | 19 |
| TV Show | 1989 | Tales from the Crypt | Dr. Beneloy | 1 |
| TV Show | 1997 | South Park | Carlos Ramirez (voice) | 1 |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 2005 | Mind of Mencia | | 2 |
| TV Show | 2002 | George Lopez | Lalo | 1 |
| TV Show | 2012 | Inside Comedy | Self | 1 |
| TV Show | 1992 | The Golden Palace | Chuy Castillos | 24 |
| TV Show | 2004 | Lost | David Reyes | 3 |
| TV Show | 2003 | Mike's Super Short Show | | 1 |
| TV Show | 2008 | Free Radio | Cheech Marin | 1 |
| TV Show | 1981 | Elvira's Movie Macabre | Devil | 140 |
| TV Show | 2006 | Psych | Deacon Jones | 1 |
| TV Show | 2014 | Jane the Virgin | Edward | 3 |
| TV Show | 2023 | The Muppets Mayhem | Cheech Marin | 1 |
| TV Show | 2021 | Maya and the Three | Hura/Can (voice) | 9 |
| TV Show | 2012 | ¡Rob! | Fernando | 8 |
| TV Show | 2005 | The Princes of Malibu | Self | 1 |
| TV Show | 2022 | Generation Gap | Self - Celebrity Guest | 1 |
| TV Show | 1997 | Behind the Music | Self | 1 |
| TV Show | 1987 | Married... with Children | Buck the Dog (voice) | 3 |
| TV Show | 2012 | Gotham Comedy Live | Self - Host | 2 |
| TV Show | 1984 | MTV Video Music Awards | Self | 1 |
| TV Show | 1995 | Santo Bugito | Lencho the Flea (voice) | 1 |
| TV Show | 1971 | Rollin' On The River | | 1 |
| TV Show | 1995 | Happily Ever After: Fairy Tales for Every Child | Alberto (voice) | 1 |
| TV Show | 2021 | Home Economics | Roberto | 2 |
| TV Show | 1993 | Raw | | 1 |
| TV Show | 2005 | Grey's Anatomy | Otis Sharon | 1 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 1997 | Classic Albums | Self | 1 |
| TV Show | 1990 | Dream On | Waiter | 1 |
| TV Show | 2022 | Cars on the Road | Ramone (voice) | 1 |
| TV Show | 2005 | American Dad! | Horatio (voice) | 1 |
| TV Show | 2022 | The Legend of Vox Machina | Trinket (voice) | 1 |
| TV Show | 2018 | Rob Riggle's Ski Master Academy | Condor de Bogota | 8 |
| TV Show | 1992 | Ring of the Musketeers | Burt Aramis | 4 |
| TV Show | 2018 | Lodge 49 | | 3 |
| TV Show | 2024 | Primos | Pop Ramirez (voice) | 55 |
| TV Show | 2011 | Bubble Guppies | Fogzilla (voice) | 1 |
| TV Show | 2011 | Off the Map | Papa Ucumari | 2 |
| TV Show | 2012 | Anger Management | Hector | 1 |
| TV Show | 1998 | Hollywood Squares | | 5 |
| TV Show | 2024 | LEGO Pixar: BrickToons | Ramone (voice) | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 1 |
| TV Show | 2022 | Chibiverse | Pop Ramirez (voice) | 1 |
