| Movie | 1997 | Face/Off | Sasha Hassler | |
| Movie | 1992 | The Player | Whitney Gersh | |
| Movie | 2001 | Driven | Cathy Heguy | |
| Movie | 1995 | Showgirls | Cristal Connors | |
| Movie | 1986 | Pretty in Pink | Girl Friend/Gym Class - Trombley | |
| Movie | 2007 | P.S. I Love You | Sharon | |
| Movie | 1998 | Palmetto | Nina | |
| Movie | 2006 | Dreamland | Mary | |
| Movie | 2002 | Demonlover | Elaine Si Gibril | |
| Movie | 1999 | The Insider | Helen Caperelli | |
| Movie | 1986 | 3:15 the Moment of Truth | Cobrettes | |
| Movie | 1996 | Bound | Corky | |
| Movie | 2004 | Out of Season | Eileen Phillips | |
| Movie | 2006 | Man About Town | Arlene Kreiner | |
| Movie | 1988 | Red Heat | Cat Manzetti | |
| Movie | 2004 | Three Way | Florence DeCroix Hagen | |
| Movie | 2003 | Prey for Rock & Roll | Jacki | |
| Movie | 2007 | Delirious | Dana | |
| Movie | 2001 | Picture Claire | Lily Warden | |
| Movie | 2023 | Thanksgiving | Amanda Collins | |
| Movie | 1995 | Best of the Best 3: No Turning Back | Margo Preston | |
| Movie | 2024 | Tapawingo | Dot | |
| Movie | 1991 | Out for Justice | Patti Madano | |
| Movie | 1997 | This World, Then the Fireworks | Carol Lakewood Morton | |
| Movie | 1998 | Lulu on the Bridge | Hannah | |
| Movie | 2005 | Category 7: The End of the World | FEMA Director Judith Carr | |
| Movie | 1999 | Guinevere | Billie | |
| Movie | 2005 | One Last Thing... | Arlene | |
| Movie | 1997 | Touch | Debra Lusanne | |
| Movie | 2008 | Just Business | Marty Jameson | |
| Movie | 2006 | Kettle of Fish | Ginger | |
| Movie | 1999 | Black & White | Nora 'Hugs' Hugosian | |
| Movie | 2010 | Love Ranch | Irene | |
| Movie | 2012 | LOL | Kathy | |
| Movie | 2010 | Five Minarets in New York | Maria | |
| Movie | 2010 | Across the Line: The Exodus of Charlie Wright | Mariel Garza | |
| Movie | 2002 | Borderline | Dr. Lila Coletti | |
| Movie | 2012 | Killer Joe | Sharla Smith | |
| Movie | 2022 | With/In Volume 2 | | |
| Movie | 2020 | Time Warp Vol. 2: Horror and Sci-Fi | Self | |
| Movie | 1998 | Legalese | Angela Beale | |
| Movie | 1987 | Sweet Revenge | K.C. | |
| Movie | 2025 | High Rollers | Amelia Decker | |
| Movie | 2012 | Breathless | Lorna | |
| Movie | 1990 | Voodoo Dawn | Tina | |
| Movie | 2024 | The Trainer | Roberta "Bob" Campbell | |
| Movie | 1998 | One Tough Cop | Joey O'Hara | |
| Movie | 2013 | Dealin' with Idiots | Sophie | |
| Movie | 1994 | Flinch | Daphne James | |
| Movie | 2014 | The Scribbler | Cleo | |
| Movie | 2013 | House of Versace | Donatella Versace | |
| Movie | 1984 | The Cars: Heartbeat City | | |
| Movie | 2013 | Hunt for the Labyrinth Killer | Karen Donovan | |
| Movie | 1992 | Miss Rose White | Angie | |
| Movie | 2014 | Mall | Donna | |
| Movie | 1993 | Love Matters | Heater | |
| Movie | 2003 | Totally Gay! | Self | |
| Movie | 1988 | Cocktail | Coral | |
| Movie | 2014 | The Lookalike | Lee Garner | |
| Movie | 2008 | Beer for My Horses | Cammie | |
| Movie | 2016 | Palacetor | The Clairvoyant | |
| Movie | 2015 | Staten Island Summer | Ms Greeley | |
| Movie | 1993 | Joey Breaker | Jenny Chaser | |
| Movie | 1998 | Prague Duet | Lauren Graham | |
| Movie | 2018 | Permission | Lydia | |
| Movie | 2014 | Femme Fatales with Gina Gershon and Jennifer Tilly | Self | |
| Movie | 2016 | My Dead Boyfriend | Helene | |
| Movie | N/A | Breed of Greed | Susan Wendolyn | |
| Movie | N/A | Goddess: The Fall and Rise of Showgirls | Self | |
| Movie | 2018 | The Little Mermaid | Peggy Gene | |
| Movie | 2017 | Bad Kids of Crestview Academy | Senator Wilkes | |
| Movie | 1981 | Beatlemania | Dancer | |
| Movie | 1985 | Girls Just Want to Have Fun | Dancer | |
| Movie | 1991 | City of Hope | Laurie Rinaldi | |
| Movie | 1998 | I'm Losing You | Lidia | |
| Movie | 2002 | Slackers | Girl at Trendy Club | |
| Movie | 2007 | What Love Is | Rachel | |
| Movie | 2014 | Me | Gina Gershon | |
| Movie | N/A | The Designer | | |
| Movie | 2017 | Inconceivable | Angela | |
| Movie | 2017 | Lost Cat Corona | Connie | |
| Movie | 2017 | 9/11 | Eve | |
| Movie | 2018 | After Everything | Tracy | |
| Movie | 2018 | Blockers | Cathy | |
| Movie | 2018 | Friedkin Uncut | Self | |
| Movie | 2018 | American Dresser | Sandra | |
| Movie | 2009 | The Goods: Live Hard, Sell Hard | (uncredited) | |
| Movie | 2019 | You Don't Nomi | Herself (archive footage) | |
| Movie | 2020 | Rifkin’s Festival | Sue | |
| Movie | 1989 | Suffering Bastards | Sharnetta | |
| Movie | 2020 | Cagefighter: Worlds Collide | Max Black | |
| Movie | 2003 | Comedy Central Roast of Denis Leary | Self | |
| Movie | 2020 | Time Warp Vol. 3: Comedy and Camp | Self | |
| Movie | 2006 | I Want Someone to Eat Cheese With | Self as Marty's Mother | |
| Movie | 2020 | People in Landscape | Alex's Mother | |
| Movie | 2003 | Making of 'Demonlover' | Self | |
| Movie | 2021 | The Mimic | The Woman at the Bar | |
| Movie | 2002 | The Making and Meaning of 'We Are Family' | Self | |
| Movie | 2024 | Borderlands | Moxxi | |
| Movie | 1986 | Stark: Mirror Image | Alison Cromwell | |
| Movie | 2021 | With/In Volume 2 | (segment "Shell Game") | |
| Movie | 2022 | Emily the Criminal | Alice | |
| Movie | 2007 | The Light and the Dark: The Making of 'Face/Off' | Self | |
| Movie | 2025 | Fior Di Latte | | |
| TV Show | 2001 | The Job | | 1 |
| TV Show | 2003 | All Grown Up! | | 1 |
| TV Show | 2005 | Numb3rs | Danielle Hill | 1 |
| TV Show | 2005 | American Dad! | Karen (voice) | 1 |
| TV Show | 1999 | Family Guy | Policewoman (voice) | 1 |
| TV Show | 1985 | The Twilight Zone | Laura (segment "Time and Teresa Golowitz") | 1 |
| TV Show | 2001 | Crossing Jordan | Charlie Davis | 1 |
| TV Show | 2004 | The Batman | Catwoman (voice) | 5 |
| TV Show | 1999 | Snoops | Glenn Hall | 10 |
| TV Show | 1997 | The Practice | Glenn Hall | 1 |
| TV Show | 1992 | Melrose Place | Ellen | 3 |
| TV Show | 2006 | Ugly Betty | Fabia | 3 |
| TV Show | 1951 | Hallmark Hall of Fame | Angie | 1 |
| TV Show | 2004 | Tripping the Rift | Six of One (voice) | 13 |
| TV Show | 2004 | Kevin Hill | Carly Austin | 1 |
| TV Show | 1990 | Cop Rock | | 1 |
| TV Show | 2011 | Wilfred | Gloria | 1 |
| TV Show | 2008 | The Wendy Williams Show | | 1 |
| TV Show | 2004 | Rocked with Gina Gershon | | 6 |
| TV Show | 2010 | Glory Daze | | 1 |
| TV Show | 2009 | Community | Devon's Wife | 1 |
| TV Show | 1992 | The Larry Sanders Show | Gina Gershon | 1 |
| TV Show | 2013 | Cleaners | Mother | 2 |
| TV Show | 2012 | Elementary | Elana March | 2 |
| TV Show | 2006 | Psych | Emilina Saffron | 1 |
| TV Show | 2015 | Younger | Chrissie | 1 |
| TV Show | 1992 | Sinatra | Nancy Barbato Sinatra | 2 |
| TV Show | 2005 | American Dad! | Woman / American Girl #1 (voice) | 1 |
| TV Show | 2014 | Red Oaks | Fay Getty | 15 |
| TV Show | 2000 | Curb Your Enthusiasm | Anna | 2 |
| TV Show | 1997 | Just Shoot Me! | Rhonda Ferrara | 2 |
| TV Show | 2013 | Brooklyn Nine-Nine | Melanie Hawkins | 4 |
| TV Show | 2009 | Eastbound & Down | Realtor | 1 |
| TV Show | 2015 | Sinatra: All or Nothing at All | Ava Gardner (voice) | 2 |
| TV Show | 2003 | Spider-Man: The New Animated Series | Shikata (voice) | 1 |
| TV Show | 2017 | Riverdale | Gladys Jones | 8 |
| TV Show | 2009 | Celebrity Ghost Stories | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 4 |
| TV Show | 2021 | Chucky | Gina Gershon | 1 |
| TV Show | 2008 | Life on Mars | Rita | 1 |
| TV Show | 1987 | The Days and Nights of Molly Dodd | Randy Lewis | 3 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 2 |
| TV Show | 2009 | Glee | Pam Anderson | 1 |
| TV Show | 2020 | Awkwafina Is Nora from Queens | Toe / Dr. Emily Cohen | 1 |
| TV Show | 2017 | The Good Fight | Melania Trump | 1 |
| TV Show | 2020 | Betty | Oracle | 1 |
| TV Show | 2003 | Comedy Central Roasts | Self | 1 |
| TV Show | 2005 | Category 7: The End of the World | FEMA Director Judith Carr | 2 |
| TV Show | 2009 | Everything She Ever Wanted | Pat Allanson | 4 |
| TV Show | 2024 | Elsbeth | Dr. Vanessa Holmes | 2 |
| TV Show | 2004 | Rescue Me | Valerie | 7 |
| TV Show | 2014 | Z Nation | La Reina | 3 |
| TV Show | 2018 | New Amsterdam | Jeanie Bloom | 5 |
| TV Show | 2012 | Anger Management | Mandy | 1 |
| TV Show | 2024 | Doctor Odyssey | Lenore Laurent | 2 |
| TV Show | 2025 | The Assassin | Marie | 6 |
