| Movie | 1993 | Malice | Det. Dana Harris | |
| Movie | 1996 | The Associate | Camille Scott | |
| Movie | 2004 | Broadway's Lost Treasures II | Host (segment "All Singing, All Dancing") | |
| Movie | 1995 | Jumanji | Nora Shepherd | |
| Movie | 1990 | Green Card | Lauren Adler | |
| Movie | 1998 | Celebrity | Nina - the Hooker | |
| Movie | 2003 | Le Divorce | Julia Manchevering | |
| Movie | 1998 | The Faculty | Principal Valerie Drake | |
| Movie | 2004 | The Big Bounce | Alison Ritchie | |
| Movie | 1999 | Liberty Heights | Ada Kurtzman | |
| Movie | 2003 | How to Lose a Guy in 10 Days | Lana Jong | |
| Movie | 2021 | tick, tick... BOOM! | "Sunday" Legend #9 | |
| Movie | 2003 | The Adventures of Tom Thumb and Thumbelina | Thumbelina's Mother (voice) | |
| Movie | 2000 | An Extremely Goofy Movie | Sylvia Marpole (voice) | |
| Movie | 2002 | Tadpole | Diane Lodder | |
| Movie | 2001 | Sounds from a Town I Love | | |
| Movie | 1996 | All Dogs Go to Heaven 2 | Anabelle (voice) | |
| Movie | 2008 | Adopt a Sailor | Patricia | |
| Movie | 2006 | Game 6 | Joanna Bourne | |
| Movie | 1998 | An All Dogs Christmas Carol | Anabelle / Belladonna (voice) | |
| Movie | 2006 | Chicago: The Musical | | |
| Movie | 2012 | Defiant Requiem | (voice) | |
| Movie | 1999 | Dash and Lilly | Dorothy Parker | |
| Movie | 1993 | The Paint Job | Margaret | |
| Movie | 2001 | My Favorite Broadway: The Love Songs | Self - Performer | |
| Movie | 1989 | Say Anything... | Mrs. Evans | |
| Movie | 1991 | Bugsy | Countess di Frasso | |
| Movie | 1996 | The Adventures of Pinocchio | Felinet | |
| Movie | 2017 | Broadway: The Next Generation | Self | |
| Movie | 2013 | Browsers | Julianna Mancuso-Bruni | |
| Movie | 2004 | Frasier: Analyzing the Laughter | Dr. Lilith Sternin | |
| Movie | 2017 | Humor Me | C.C. Rudin | |
| Movie | 2013 | Just Gender | | |
| Movie | 1999 | Summer of Sam | Gloria | |
| Movie | 1999 | Getting to Know You | Trix | |
| Movie | 1997 | The Music of Kander & Ebb: Razzle Dazzle | Self (archive footage) | |
| Movie | 1999 | My Favorite Broadway: The Leading Ladies | Self - Performer | |
| Movie | 1996 | Dear Diary | Annie | |
| Movie | 2019 | Jumanji: The Next Level | Nora | |
| Movie | 2000 | Cupid & Cate | Francesca | |
| Movie | 2009 | Fame | Ms. Kraft | |
| Movie | 2020 | Modern Persuasion | Vanessa PErry | |
| Movie | 1990 | Without Her Consent | Gloria Allred | |
| Movie | 1990 | Disneyland's 35th Anniversary Special | Self | |
| Movie | 1990 | Unspeakable Acts | Susan Maxwell | |
| Movie | 2013 | Cabaret: The Musical That Changed Musicals | Self | |
| Movie | 2025 | Broadway’s Leading Ladies | | |
| Movie | 2001 | The Concert for New York City | | |
| Movie | N/A | I Came with Earrings | | |
| Movie | N/A | Don't Say Good Luck | | |
| TV Show | 1994 | Duckman | Tamara La Boinque (voice) | 1 |
| TV Show | 1982 | Cheers | Lilith Sternin | 79 |
| TV Show | 2004 | The Tony Danza Show | Self - Guest | 2 |
| TV Show | 1987 | Star Trek: The Next Generation | Lanel | 1 |
| TV Show | 1982 | Fame | | 1 |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 1981 | Simon & Simon | | 1 |
| TV Show | 1999 | Strangers with Candy | Bebe Neuwirth | 1 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 2022 | Julia | Avis | 16 |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 2000 | Deadline | Nikki Masucci | 13 |
| TV Show | 1990 | Wings | Dr. Lilith Sternin-Crane | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Nina Laszlo | 1 |
| TV Show | 1993 | Wild Palms | Tabba Schwartzkopf | 5 |
| TV Show | 1994 | Aladdin | | 3 |
| TV Show | 2005 | Law & Order: Trial by Jury | Tracey Kibre | 13 |
| TV Show | 1993 | The Adventures of Pete & Pete | The Mailcarrier | 1 |
| TV Show | 1984 | Jeopardy! | | 1 |
| TV Show | 1995 | NewsRadio | Sandi Angelini | 1 |
| TV Show | 2002 | Cyberchase | Binky the Cat (voice) | 2 |
| TV Show | 2021 | Ultra City Smiths | Lady Andrea The Giant (voice) | 6 |
| TV Show | 1998 | Will & Grace | Bebe Neuwirth | 1 |
| TV Show | 1982 | Late Night with David Letterman | Self | 1 |
| TV Show | 1951 | Hallmark Hall of Fame | Francesca | 1 |
| TV Show | 1996 | All Dogs Go To Heaven: The Series | Anabelle (voice) | 41 |
| TV Show | 1996 | Jungle Cubs | | 1 |
| TV Show | 1989 | The Famous Teddy Z | | 1 |
| TV Show | 2009 | The Cleveland Show | | 1 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self - Guest | 1 |
| TV Show | 2003 | VH1 Goes Inside | | 1 |
| TV Show | 2010 | Blue Bloods | Kelly Peterson | 6 |
| TV Show | 2014 | Madam Secretary | Nadine Tolliver | 90 |
| TV Show | 2021 | Teenage Euthanasia | Baba (voice) | 17 |
| TV Show | 1996 | Sabrina, the Teenage Witch | Juliette | 1 |
| TV Show | 2023 | Captain Fall | Alexis Fall (voice) | 3 |
| TV Show | 1995 | Freakazoid! | Deadpan (voice) | 1 |
| TV Show | 1994 | The Magic School Bus | (voice) | 1 |
| TV Show | 1993 | Frasier | Lilith Sternin | 12 |
| TV Show | 2009 | The Good Wife | Judge Claudia Friend | 3 |
| TV Show | 1956 | Tony Awards | Self - Presenter | 1 |
| TV Show | 1997 | Pepper Ann | Ms. Bladdar (voice) | 1 |
| TV Show | 2020 | Duncanville | Patricia (voice) | 1 |
| TV Show | 2023 | Frasier | Dr. Lilith Sternin | 1 |
| TV Show | 2017 | The Good Fight | Judge Claudia Friend | 2 |
| TV Show | 2016 | Match Game | Self - Panelist | 1 |
| TV Show | 2020 | Stars in the House | Self - Special Guest | 2 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Tracey Kibre | 1 |
| TV Show | 2002 | Hack | Faith O'Connor | 5 |
| TV Show | 2017 | DuckTales | Emma Glamour (voice) | 1 |
| TV Show | 2014 | Over the Garden Wall | Margueritte Grey (voice) | 1 |
| TV Show | 1971 | Great Performances | Self | 2 |
| TV Show | 2020 | The Flight Attendant | Diana Carlisle | 2 |
