| Movie | 1985 | Back to the Future | Lorraine Baines | |
| Movie | 1989 | Back to the Future Part II | Lorraine | |
| Movie | 1990 | Back to the Future Part III | Maggie McFly / Lorraine McFly | |
| Movie | 1984 | Red Dawn | Erica | |
| Movie | 1986 | Howard the Duck | Beverly Switzler | |
| Movie | 2021 | Next Stop, Christmas | Evelyn | |
| Movie | 1994 | The Little Rascals | Ms. Roberts | |
| Movie | 2008 | Senior Skip Day | Cathleen Harris | |
| Movie | 2008 | Spy School | Claire Miller | |
| Movie | N/A | Queen | Dr. Page | |
| Movie | 2022 | Retour vers le futur : Voyage dans le temps, American Dream & rock'n'roll | Self | |
| Movie | 2009 | Splinterheads | Susan Frost | |
| Movie | 1993 | Dennis the Menace | Alice Mitchell | |
| Movie | 1992 | Article 99 | Dr. Robin Van Dorn | |
| Movie | 1988 | Casual Sex? | Stacy | |
| Movie | 1990 | Montana | Peg Guthrie | |
| Movie | 2003 | Stealing Christmas | Sarah Gibson | |
| Movie | 1986 | SpaceCamp | Kathryn | |
| Movie | 1987 | Some Kind of Wonderful | Amanda Jones | |
| Movie | 2010 | Rock Slyde | Master Bartologist | |
| Movie | 2007 | California Dreaming | Ginger Gainor | |
| Movie | 2010 | Adventures of a Teenage Dragonslayer | Laura | |
| Movie | 1984 | The Wild Life | Anita | |
| Movie | 2008 | Final Approach | Alicia Bender | |
| Movie | 2008 | Exit Speed | Maudie McMinn | |
| Movie | 2007 | A Life Interrupted | Debbie Smith | |
| Movie | 1983 | Jaws 3-D | Kelly Ann Bukowski | |
| Movie | 1983 | All the Right Moves | Lisa | |
| Movie | 2005 | Jane Doe: Now You See It, Now You Don't | Cathy Davis | |
| Movie | 2005 | Jane Doe: Vanishing Act | Cathy Davis | |
| Movie | 2005 | Jane Doe: The Wrong Face | Cathy Davis | |
| Movie | 2011 | Mayor Cupcake | Mary Maroni | |
| Movie | 2008 | The Christmas Clause | Sophie | |
| Movie | 2012 | Thin Ice | Jo Ann Prohaska | |
| Movie | 2012 | The Trouble with the Truth | Emily | |
| Movie | N/A | A Pretty Good Movie | Ramona | |
| Movie | 2007 | Jane Doe: Ties That Bind | Cathy Davis / Jane Doe | |
| Movie | 1988 | Going Undercover | Marigold de la Hunt | |
| Movie | 2011 | J. Edgar | Lela Rogers | |
| Movie | 2009 | Fatal Secrets | Rebecca | |
| Movie | 2006 | The Making of Some Kind of Wonderful | Self | |
| Movie | 1988 | The Wizard of Loneliness | Sybil | |
| Movie | 2005 | Jane Doe: Til Death Do Us Part | Cathy Davis | |
| Movie | 2007 | Jane Doe: How to Fire Your Boss | Cathy Davis | |
| Movie | 2012 | Love at the Christmas Table | Elissa Beth | |
| Movie | 2006 | Jane Doe: Yes, I Remember It Well | Cathy Davis | |
| Movie | 2006 | Jane Doe: The Harder They Fall | Cathy Davis | |
| Movie | 2008 | Jane Doe: Eye of the Beholder | Cathy Davis / Jane Doe | |
| Movie | N/A | You Are Here | Helen | |
| Movie | 2011 | The Cabin | Lily MacDougal | |
| Movie | 2012 | John Hughes: Life Moves Pretty Fast | Self | |
| Movie | 2005 | Come Away Home | Carol | |
| Movie | 2022 | Unplugging | Perkins | |
| Movie | 2002 | Fish Don't Blink | Clara | |
| Movie | 1994 | The Substitute Wife | Amy Hightower | |
| Movie | 2013 | Call Me Crazy: A Five Film | Julia | |
| Movie | 1989 | Nightbreaker | Sally Matthews | |
| Movie | 2003 | Haunted Lighthouse 4-D | Peg Van Legge | |
| Movie | 2012 | Bound by Flesh | Voiceover | |
| Movie | 2014 | Ping Pong Summer | Mrs. Miracle | |
| Movie | 2014 | Left Behind | Irene Steele | |
| Movie | 1998 | The Unknown Cyclist | Melissa Cavatelli | |
| Movie | 1996 | The Right to Remain Silent | Christine Paley | |
| Movie | 1993 | The Beverly Hillbillies | Laura Jackson | |
| Movie | 2022 | Ten Tricks | Grace | |
| Movie | 2022 | The Disappearance of Cari Farver | Nancy Farver | |
| Movie | 2024 | BRATS | Self | |
| Movie | 2015 | Back in Time | Self | |
| Movie | 2013 | Milius | Self | |
| Movie | 2019 | Cool Cat's Crazy Dream | Dream World Lea | |
| Movie | 1993 | Stolen Babies | Annie Beales | |
| Movie | 2011 | Game of Your Life | Abbie | |
| Movie | 2015 | Keith Lemon's Back t'Future Tribute | Self | |
| Movie | 1995 | The Unspoken Truth | Brianne Hawkins | |
| Movie | 2016 | The Dog Lover | Liz Holloway | |
| Movie | 2006 | Looking Back at the Future | Herself | |
| Movie | 2014 | My Mother's Future Husband | René Henderson | |
| Movie | 2018 | The Year of Spectacular Men | Deb Klein | |
| Movie | 2009 | Looking Back to the Future | Self | |
| Movie | 2017 | Literally, Right Before Aaron | Deb (Adam's Mom) | |
| Movie | 2018 | Sierra Burgess Is a Loser | Mrs. Burgess | |
| Movie | 2018 | Little Women | Margaret "Marmee" March | |
| Movie | 2018 | Who We Are Now | Alana | |
| Movie | 1986 | The Making of Back to the Future | Self | |
| Movie | 2020 | Dinner in America | Betty | |
| Movie | 2010 | Tales from the Future | Self | |
| Movie | 2016 | Stars Are Already Dead | Aunt Sophia | |
| Movie | 1983 | The Making of Jaws 3-D: Sharks Don't Die | | |
| Movie | 2021 | Mark, Mary + Some Other People | Aunty Carol | |
| Movie | N/A | What If | | |
| Movie | 2025 | SEGAL | Self | |
| Movie | 2018 | Over the Hill | Sally | |
| Movie | N/A | Howard the Doc or: How I Learned to Start Quacking and Love the Bomb | Self | |
| TV Show | 2004 | The Tony Danza Show | Self - Guest | 2 |
| TV Show | 2007 | Greek | April | 1 |
| TV Show | 1994 | Friends | Caroline Duffy (uncredited) | 1 |
| TV Show | 1995 | Caroline in the City | Caroline Duffy | 97 |
| TV Show | 2000 | Ed | Liz Stevens | 3 |
| TV Show | 1989 | Tales from the Crypt | Sylvia Vane | 1 |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Michelle Osborne | 1 |
| TV Show | 2006 | Celebrity Duets | | 9 |
| TV Show | 1993 | Intimate Portrait | Self | 1 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self - Guest | 1 |
| TV Show | 2011 | Switched at Birth | Kathryn Kennish | 103 |
| TV Show | 2000 | CSI: Crime Scene Investigation | Jennifer Rhodes | 1 |
| TV Show | 1999 | Family Guy | Teenaged Girl in Diner (voice) | 1 |
| TV Show | 2013 | Whose Line Is It Anyway? | Self | 1 |
| TV Show | 2015 | The Muppets | Self | 1 |
| TV Show | 1998 | Hollywood Squares | Self - Panelist | 5 |
| TV Show | 2014 | Penn Zero: Part-Time Hero | Vonnie (voice) | 61 |
| TV Show | 2005 | Dancing with the Stars | Self - Contestant | 11 |
| TV Show | 2020 | Star Trek: Picard | Diane Werner | 1 |
| TV Show | 2014 | Scorpion | Veronica Dineen | 4 |
| TV Show | 2019 | The Ready Room | Self | 1 |
| TV Show | 1998 | A Will of their Own | Amanda Steward | 2 |
| TV Show | 2021 | INVINCIBLE | Carol (voice) | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | | 1 |
| TV Show | 2007 | Head Case | Self | 1 |
| TV Show | 1992 | The Larry Sanders Show | Lea Thompson | 1 |
| TV Show | 2015 | Celebrity Family Feud | Self | 1 |
| TV Show | 2013 | The Goldbergs | Fran | 2 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self - Guest | 1 |
| TV Show | 2020 | Stars in the House | Self | 1 |
| TV Show | 2018 | 25 Words or Less | Self | 2 |
| TV Show | 2023 | The Spencer Sisters | Victoria Spencer | 10 |
| TV Show | 2024 | The Chicken Sisters | Nancy Hillier | 16 |
| TV Show | 2005 | American Dad! | Caroline Duffy (voice) | 1 |
| TV Show | 1999 | Family Guy | Lorraine McFly (voice) | 1 |
| TV Show | 2020 | Reunited Apart | Self | 1 |
| TV Show | 2014 | A to Z | Lea Thompson | 1 |
| TV Show | 2002 | For the People | Chief Deputy District Attorney Camille Paris | 18 |
| TV Show | 2018 | Back to the Future: The Hill Valley Chronicles | Lorraine Baines-McFly | 11 |
