| Movie | 1973 | Live and Let Die | Solitaire | |
| Movie | 1974 | Frankenstein: The True Story | Agatha / Prima | |
| Movie | 1994 | It's Alive: The True Story of Frankenstein | Self | |
| Movie | 2017 | The Female Brain | Cheryl | |
| Movie | 1989 | The French Revolution | Marie Antoinette | |
| Movie | 1983 | Jamaica Inn | Mary Yellan | |
| Movie | 1978 | Love’s Dark Ride | Diana | |
| Movie | 1982 | The Scarlet Pimpernel | Marguerite St. Just | |
| Movie | 1977 | Sinbad and the Eye of the Tiger | Princess Farah | |
| Movie | 1999 | Dr. Quinn Medicine Woman: The Movie | Dr. Michaela 'Dr. Mike' Quinn | |
| Movie | 2005 | Wedding Crashers | Kathleen Cleary | |
| Movie | 2002 | Bond Girls Are Forever | Solitaire, 'Live and Let Die' (archive footage) | |
| Movie | 1998 | The New Swiss Family Robinson | Anna Robinson | |
| Movie | 1980 | Oh! Heavenly Dog | Jackie | |
| Movie | 2006 | Blind Dating | Dr. Evans | |
| Movie | 2009 | The Velveteen Rabbit | Mom (voice) | |
| Movie | 1985 | Head Office | Jane Caldwell | |
| Movie | 2009 | Wake | Mrs. Reitman | |
| Movie | 2001 | Dr. Quinn, Medicine Woman: The Heart Within | Dr. Michaela 'Dr. Mike' Quinn | |
| Movie | 1991 | Voices That Care | Self - Choir Member | |
| Movie | 1980 | Somewhere in Time | Elise McKenna | |
| Movie | 2007 | After Sex | Janet | |
| Movie | 1998 | Quest for Camelot | Juliana (voice) | |
| Movie | 1997 | Big Guns Talk: The Story of the Western | Self | |
| Movie | 2000 | Yesterday's Children | Jenny Cole / Mary Sutton | |
| Movie | 2011 | Touching Wild Horses | Fiona Kelsey | |
| Movie | 2011 | The Family Tree | Grandma Ilene | |
| Movie | 1984 | Lassiter | Sara Wells | |
| Movie | 2002 | Heart of a Stranger | Jill Maddox | |
| Movie | 1990 | Nickelodeon Studios Opening Day Celebration! | | |
| Movie | 2023 | Puppy Love | Diane Matthews | |
| Movie | 1970 | The Only Way | Lillian Stein | |
| Movie | 2011 | Love, Wedding, Marriage | Betty | |
| Movie | 2012 | Freeloaders | Carolyn | |
| Movie | 1988 | Onassis: The Richest Man in the World | Maria Callas | |
| Movie | 1977 | US Against the World | Self | |
| Movie | 1989 | 50 Years of Television: A Golden Celebration | Self - Host | |
| Movie | 2012 | Lake Effects | Vivian | |
| Movie | 1973 | The Big Screen | Self | |
| Movie | 1988 | An Audience With Victoria Wood | Self | |
| Movie | 2013 | Austenland | Mrs. Wattlesbrook | |
| Movie | 1990 | Angel of Death | Laura Hendricks | |
| Movie | 2011 | The Voyages of Young Doctor Dolittle | Polynesia (voice) | |
| Movie | 2011 | Perfectly Prudence | Prudence MacIntyre | |
| Movie | 2000 | Enslavement: The True Story of Fanny Kemble | Fanny Kemble Butler | |
| Movie | 2013 | Lovestruck: The Musical | Harper Hutton | |
| Movie | 1988 | The Tunnel | Maria Iribarne | |
| Movie | 1978 | The Four Feathers | Ethne Eustace | |
| Movie | 1990 | Matters of the Heart | Hadley Norman | |
| Movie | 1985 | Obsessed with a Married Woman | Diane Putnam | |
| Movie | 2000 | Murder in the Mirror | Mary Kost Richland | |
| Movie | 2011 | Bob Ross: The Happy Painter | Self | |
| Movie | 1999 | A Memory in My Heart | Rebecca Blake | |
| Movie | 1992 | Are You Lonesome Tonight? | Adrienne Welles | |
| Movie | 1988 | Keys to Freedom | Gillian | |
| Movie | 1978 | Battlestar Galactica | Serina | |
| Movie | 1977 | Killer on Board | Jan | |
| Movie | 1988 | The Woman He Loved | Wallis Simpson | |
| Movie | 2014 | Jake Squared | Joanne | |
| Movie | 2008 | Dear Prudence | Prudence McCoy | |
| Movie | 2013 | An American Girl: Saige Paints the Sky | Mimi Copeland | |
| Movie | 1998 | Roxanne's Best Christmas Ever | Roxanne (voice) | |
| Movie | 2006 | The Beach Party at the Threshold of Hell | President Lauren Coffey | |
| Movie | 2004 | The Littlest Light on the Christmas Tree | Maggie Wiggins (Voice) | |
| Movie | 1993 | Praying Mantis | Linda Crandell | |
| Movie | 1977 | Benny & Barney: Las Vegas Undercover | Margie Parks | |
| Movie | 2014 | A Royal Christmas | Queen Isadora | |
| Movie | 1973 | Bond 1973: The Lost Documentary | Self | |
| Movie | 2023 | Dick Van Dyke: 98 Years of Magic | Self | |
| Movie | 2024 | Irish Wish | Rosemary Kelly | |
| Movie | 2022 | A Christmas Spark | Molly | |
| Movie | 2012 | Once Upon A Christmas Featuring Jane Seymour and Nathan Gunn | Self | |
| Movie | 1999 | The Children are Watching | Self | |
| Movie | 2015 | Bereave | Evelyn | |
| Movie | 2014 | Love by Design | Vivien | |
| Movie | 2015 | About Scout | Gloria | |
| Movie | 1984 | Dark Mirror | Leigh Cullen / Tracy Cullen | |
| Movie | 2014 | Unknown Heart | Sally Haynes | |
| Movie | 2002 | Best Ever Bond | Self / Solitaire | |
| Movie | 1983 | The Haunting Passion | Julia Evans | |
| Movie | 1983 | The Phantom of the Opera | Elena Korvin/Maria Gianelli | |
| Movie | 1979 | Dallas Cowboys Cheerleaders | Laura Cole | |
| Movie | 1985 | Night of 100 Stars II | Self | |
| Movie | 2003 | Christmas in Hollywood | Self (archive footage) | |
| Movie | 1994 | A Passion for Justice: The Hazel Brannon Smith Story | Hazel Brannon Smith | |
| Movie | 2016 | Fifty Shades of Black | Claire | |
| Movie | 2016 | High Strung | Oksana | |
| Movie | 1987 | The Grand Knockout Tournament | Self | |
| Movie | 2014 | Handel's Messiah | Narrator | |
| Movie | 1972 | Young Winston | Pamela Plowden | |
| Movie | 2001 | Blackout | Kathy Robbins | |
| Movie | 1969 | Oh! What a Lovely War | Chorus Girl (uncredited) | |
| Movie | 2017 | Becoming Bond | Maggie | |
| Movie | 1980 | Challenge of the Tiger | Jane Seymour (cameo / uncredited) | |
| Movie | 2017 | Sandy Wexler | Cindy Marvelle | |
| Movie | 2020 | The War with Grandpa | Diane | |
| Movie | 2017 | Pray for Rain | Olivia Gardner | |
| Movie | 1976 | To Die... To Sleep... Perchance to Dream | Luisa | |
| Movie | 2017 | Just Getting Started | Delilah | |
| Movie | 2017 | And the Winner Isn't | Self | |
| Movie | 1992 | Sunstroke | Teresa Winters | |
| Movie | 2018 | Better Start Running | | |
| Movie | 1976 | The Story of David | Bathsheba | |
| Movie | 2018 | Little Italy | Corrine | |
| Movie | 2020 | Friendsgiving | Helen | |
| Movie | 2018 | Mistrust | Veronica Malloy | |
| Movie | 1996 | A Hollywood Christmas | | |
| Movie | 1998 | A Marriage of Convenience | Christine 'Chris' Winslow | |
| Movie | 2018 | High Strung Free Dance | Oksana | |
| Movie | 2018 | Buttons | Mrs. Browning | |
| Movie | 1997 | The Absolute Truth | Alison Reid | |
| Movie | 2018 | CinemAbility: The Art of Inclusion | Self - Narrator | |
| Movie | 1998 | Hemingway: Winner Take Nothing | Self | |
| Movie | 1973 | The Best Pair of Legs in the Business | Kim Thorn | |
| Movie | 2016 | There's Only One America's Team | | |
| Movie | 1999 | Inside 'Live and Let Die' | | |
| Movie | 1997 | The Secrets of 007 | Self | |
| Movie | 2021 | Roll Up Your Sleeves | Self | |
| Movie | 2009 | The Assistants | Sandy Goldman | |
| Movie | 2022 | Ruby's Choice | Ruby | |
| Movie | N/A | And You Are? | | |
| Movie | 2024 | From Roger Moore with Love | Self | |
| Movie | 2000 | Back To "Somewhere In Time" | Self | |
| Movie | 1993 | Heidi | Fräulein Rottenmeier | |
| Movie | 1984 | The Stars Salute the U.S. Olympic Team | | |
| Movie | 1984 | Another Audience with Dame Edna Everage | Self | |
| TV Show | 2005 | How I Met Your Mother | Professor Lewis | 1 |
| TV Show | 2009 | Castle | Gloria Chambers | 1 |
| TV Show | 2007 | In Case of Emergency | | 3 |
| TV Show | 1993 | The Nanny | Jane Seymour | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Debra Connor | 1 |
| TV Show | 1997 | Dharma & Greg | Jane Seymour | 1 |
| TV Show | 1993 | Dr. Quinn, Medicine Woman | Michaela Quinn | 149 |
| TV Show | 1975 | The Hanged Man | Laura Burnett | 1 |
| TV Show | 2016 | Anh's Brush with Fame | Self | 1 |
| TV Show | 2012 | Men At Work | Bridget | 1 |
| TV Show | 2006 | Modern Men | Dr. Victoria Stangel | 7 |
| TV Show | 1970 | McCloud | | 1 |
| TV Show | 1973 | Orson Welles' Great Mysteries | Veronique d' Aubray | 1 |
| TV Show | 1976 | Captains and the Kings | Marjorie Chisholm Armagh | 8 |
| TV Show | 1993 | Diagnosis: Murder | Jane Seymour | 1 |
| TV Show | 1981 | East of Eden | Kate Trask | 3 |
| TV Show | 1972 | The Strauss Family | Karoline | 8 |
| TV Show | 1971 | The Onedin Line | Emma Fogarty | 1 |
| TV Show | 1983 | Jamaica Inn | Mary Yellan | 3 |
| TV Show | 1988 | War and Remembrance | Natalie Henry | 12 |
| TV Show | 2012 | Ben and Kate | Wendy | 1 |
| TV Show | 1988 | Jack the Ripper | Emma | 2 |
| TV Show | 2014 | Jane the Virgin | Amanda Elaine | 3 |
| TV Show | 1978 | The Magic of David Copperfield | | 1 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 2004 | Who Do You Think You Are? | Self | 1 |
| TV Show | 1956 | Tony Awards | Self - Presenter | 2 |
| TV Show | 1987 | The Dame Edna Experience | Self | 1 |
| TV Show | 2005 | Dancing with the Stars | Self - Contestant | 14 |
| TV Show | 1976 | Our Mutual Friend | Miss Bella Wilfer | 7 |
| TV Show | 2005 | Nigella | Self | 1 |
| TV Show | 2014 | Forever | Maureen Delacroix | 1 |
| TV Show | 1986 | Crossings | Hillary Burnham | 3 |
| TV Show | 1978 | An Audience with... | Self | 2 |
| TV Show | 2016 | Hooten & The Lady | | 1 |
| TV Show | 1998 | Hollywood Squares | Self - Panelist | 5 |
| TV Show | 2022 | Harry Wild | Harry Wild | 26 |
| TV Show | 2020 | B Positive | Bette | 16 |
| TV Show | 2011 | Franklin & Bash | Colleen Bash | 4 |
| TV Show | 1977 | Seventh Avenue | Eva Meyers | 3 |
| TV Show | 1978 | The Awakening Land | Genny Luckett | 3 |
| TV Show | 1984 | The Sun Also Rises | Brett Ashley | 2 |
| TV Show | 1993 | Heidi | Fräulein Rottenmeier | 2 |
| TV Show | 1991 | Memories of Midnight | Catherine Alexander Douglas | 2 |
| TV Show | 2001 | Smallville | Genevieve Teague | 6 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 1 |
| TV Show | 1997 | The View | Self | 3 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 2005 | My Name Is Earl | Jane Seymour | 1 |
| TV Show | 2018 | I Feel Bad | Chewey's Mom | 1 |
| TV Show | 2018 | The Kominsky Method | Madelyn | 5 |
| TV Show | 2018 | Let's Get Physical | Janet Force | 8 |
| TV Show | 1971 | The Onedin Line | Emma Callon | 8 |
| TV Show | 1993 | Intimate Portrait | Self (archive footage) | 1 |
| TV Show | 2013 | Through the Keyhole | Self | 1 |
| TV Show | 1996 | Ruby Wax Meets | | 1 |
| TV Show | 1978 | Battlestar Galactica | Serina | 3 |
| TV Show | 1986 | Wedden, dat..? | Self | 1 |
| TV Show | 1992 | Vicki! | Self | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Presenter | 4 |
| TV Show | 1971 | Great Performances | Self | 1 |
| TV Show | 2006 | The Megan Mullally Show | Self - Guest | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Audience Member | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee | 3 |
| TV Show | 1944 | Golden Globe Awards | Self - Hostess | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee / Presenter | 1 |
| TV Show | 1973 | The American Film Institute Salute to ... | Self | 1 |
| TV Show | 2025 | The Twelve Dates of Christmas | Evelyn | 1 |
| TV Show | 1947 | Kraft Television Theatre | | 1 |
| TV Show | 1989 | The French Revolution | Marie Antoinette | 2 |
| TV Show | 2025 | Relative Secrets | Self - Host | 4 |
| TV Show | N/A | Glow and Darkness | Eleanor of Aquitaine | 1 |
