| Movie | 2003 | My Life Without Me | Ann's Mother | |
| Movie | 1983 | Videodrome | Nicki Brand | |
| Movie | 2003 | The Tulse Luper Suitcases, Part 1: The Moab Story | Fastidieux | |
| Movie | 2005 | A Life in Suitcases | Fastidieux | |
| Movie | 1980 | Roadie | Debbie Harry | |
| Movie | 1990 | Tales from the Darkside: The Movie | Betty (Wraparound Story) | |
| Movie | 2001 | The N.Y. Friars Club Roast of Hugh Hefner | Self | |
| Movie | 1993 | Body Bags | The Nurse | |
| Movie | 1995 | Heavy | Delores | |
| Movie | 2006 | Full Grown Men | Beauty | |
| Movie | 2019 | My View: Clem Burke | Self (Archive) | |
| Movie | 2002 | Try Seventeen | Ma Mabley | |
| Movie | 2003 | A Good Night to Die | Madison | |
| Movie | 1990 | Mother Goose Rock 'n' Rhyme | Old Woman Who Lived in a Shoe | |
| Movie | 1978 | The Foreigner | Dee Trik | |
| Movie | 1988 | Satisfaction | Tina | |
| Movie | 1983 | Rock & Rule | Angel (singing voice) | |
| Movie | 2005 | I Remember You Now... | Margaret | |
| Movie | 1993 | Changing Fashions | | |
| Movie | 1999 | Six Ways to Sunday | Kate Odum | |
| Movie | 1979 | Mr. Mike's Mondo Video | Self | |
| Movie | 2001 | The Fluffer | Marcella | |
| Movie | 1999 | Blondie - Live in New York | Self | |
| Movie | 1989 | New York Stories | Girl at Blind Alley | |
| Movie | 1991 | Intimate Stranger | Cory Wheeler | |
| Movie | 2000 | The American Nightmare | Self | |
| Movie | 2006 | Too Tough to Die: A Tribute to Johnny Ramone | Self | |
| Movie | 2010 | H.R. Giger Revealed | Self | |
| Movie | 2022 | Personality Crisis: One Night Only | Self | |
| Movie | 1980 | Union City | Lillian | |
| Movie | 2005 | Disco: Spinning The Story | self | |
| Movie | 2002 | Blondie Greatest Video Hits | Self | |
| Movie | 2023 | So Unreal | Self - Narrator (voice) | |
| Movie | 2006 | Blondie: Live at Beat Club 1978 | Self - Vocals | |
| Movie | 2013 | Harry Dean Stanton: Partly Fiction | Self | |
| Movie | 2013 | Rock 'N' Roll Exposed: The Photography of Bob Gruen | Self | |
| Movie | 2007 | NY77: The Coolest Year in Hell | Self (archive footage) (uncredited) | |
| Movie | 2004 | Ramones: We're Outta Here! | Herself | |
| Movie | 2022 | Tell Me Iggy | Self | |
| Movie | 2006 | Blondie: One Way or Another | Self | |
| Movie | 2013 | Who Shot Rock & Roll: The Film | Self | |
| Movie | 2010 | Gavin McInnes is a Fucking Asshole | Self (archive footage) | |
| Movie | 2008 | Elegy | Amy O'Hearn | |
| Movie | 2014 | River of Fundament | Singing Wake Guest | |
| Movie | 1978 | Blitzkrieg Bop! | | |
| Movie | 2014 | What Difference Does It Make? | Self | |
| Movie | 2001 | Downtown '81 | Fairy Godmother | |
| Movie | 2023 | When Blondie Came to Britain | Self | |
| Movie | 2014 | Blondie's New York and the Making of Parallel Lines | Self | |
| Movie | 2023 | Blondie at the BBC | Self | |
| Movie | 1996 | Drop Dead Rock | Thor Sturmundrang | |
| Movie | 2007 | Anamorph | Neighbor | |
| Movie | 2003 | Blondie: Good Boys | Self | |
| Movie | 1986 | Forever, Lulu | Lulu | |
| Movie | 1975 | Night Lunch | Self | |
| Movie | 1995 | Wigstock: The Movie | Self | |
| Movie | 1989 | The RollerGames World Premiere Special | Self | |
| Movie | 2024 | Catharsis | | |
| Movie | N/A | Simply The Best: The Mike Chapman Story | Self | |
| Movie | 2003 | Ghostlight | self | |
| Movie | 2016 | Mapplethorpe: Look at the Pictures | Self | |
| Movie | 2016 | Andy Warhol, Fluorescent | Self (archive footage) | |
| Movie | 2002 | Deuces Wild | Wendy | |
| Movie | 2004 | VH1 Divas 2004 | Self | |
| Movie | 2003 | The Tulse Luper Suitcases: Antwerp | | |
| Movie | 2011 | Blank City | Self | |
| Movie | 2013 | Blondie: Live at the Apollo | Self | |
| Movie | 1997 | Cop Land | Delores | |
| Movie | 1980 | Blondie: Eat to the Beat | Self | |
| Movie | 2017 | New Wave: Dare to be Different | Self - Blondie - Singer / Songwriter | |
| Movie | 2002 | What the Punk - An MVD Sampler | | |
| Movie | 1976 | The Blank Generation | Self | |
| Movie | 2003 | End of the Century: The Story of the Ramones | Self | |
| Movie | 2003 | Mayor of the Sunset Strip | Self | |
| Movie | 2003 | Spun | Neighbor | |
| Movie | 1976 | Unmade Beds | Blondie | |
| Movie | 2017 | Basquiat: Rage to Riches | Self (archive footage) | |
| Movie | 1994 | Dead Beat | Mrs. Kurtz | |
| Movie | 2002 | Stormy Weather: The Music of Harold Arlen | Herself | |
| Movie | 2000 | Wild Boys: The Story of Duran Duran | Self | |
| Movie | 2000 | Red Lipstick | Ezmeralda The Psychic | |
| Movie | 2005 | Blondie : Greatest Hits - Sound & Vision | Self - Performer | |
| Movie | 2005 | TV Party | Self | |
| Movie | 2009 | Downtown Calling | Self - Narrator | |
| Movie | 2018 | Bad Reputation | Self | |
| Movie | 2004 | And You Don't Stop: 30 Years of Hip-Hop | Self | |
| Movie | 2001 | 25 Years of Punk | Self | |
| Movie | 2014 | More Dangerous Songs: And the Banned Played On | Self - Performer | |
| Movie | 1994 | Rakthavira | Narrator (voice) | |
| Movie | 2017 | Blondie - Live at Round Chapel | Self | |
| Movie | 1982 | The Making of David Cronenberg's Videodrome | Interviewee | |
| Movie | 2017 | Blondie: Live at Soundstage | Self - Performer | |
| Movie | 2019 | Suzi Q | Self | |
| Movie | 2005 | Kiki and Herb Reloaded | Self | |
| Movie | 2010 | Gaze | Self (archive footage) | |
| Movie | 2001 | Andy Warhol: The Complete Picture | Self | |
| Movie | 1999 | In Bad Taste | Self | |
| Movie | 2013 | AMEX Unstaged Presents: Vampire Weekend | Self | |
| Movie | 2009 | Burning Down the House: The Story of CBGB | Self | |
| Movie | 2013 | Robert Williams Mr. Bitchin' | | |
| Movie | 1979 | The Midnight Special Legendary Performances 1979 | Self | |
| Movie | 2006 | The Midnight Special Legendary Performances: Million Sellers | Self | |
| Movie | 1995 | Dancing Barefoot | Self | |
| Movie | 2018 | Debbie Harry: Atomic Blondie | Self (archive footage) | |
| Movie | 1979 | Blondie: Live at Asbury Park Convention Hall | Self | |
| Movie | 2011 | Paul Williams Still Alive | Self (archive footage) | |
| Movie | 2002 | I Love Muppets | Self | |
| Movie | 2010 | Blondie - Live at The Enmore Theatre | | |
| Movie | 1982 | A New Face of Debbie Harry by H.R. Giger | Herself | |
| Movie | 1990 | Red Hot + Blue: A Tribute to Cole Porter | Self | |
| Movie | 1988 | Hairspray | Velma Von Tussle | |
| Movie | 1979 | Blondie in Concert | Self | |
| Movie | 1975 | Deadly Hero | Singer (uncredited) | |
| Movie | 1999 | Blondie: The Best of Musikladen Live | Herself | |
| Movie | 2005 | Face Addict | Herself | |
| Movie | 1995 | The State's 43rd Annual All-Star Halloween Special | Self | |
| Movie | 2006 | Midnight Blue, Vol. 3: Celebrities Edition | Self (archive footage) | |
| Movie | 2019 | Deborah Harry Does Not Like Interviews | Self | |
| Movie | 1991 | The Real Story of O Christmas Tree | Anneka (voice) | |
| Movie | 1982 | Blondie - Live! The Farewell Concert | Self | |
| Movie | 2019 | Wig | Self | |
| Movie | 2014 | Blondie - iTunes Festival | self | |
| Movie | 1983 | The Making of Rock & Rule | Self | |
| Movie | 2008 | New York Rock at the BBC | | |
| Movie | 2021 | The Dancing Man of L.A. | Self (archive footage) | |
| Movie | 1997 | L.A. Johns | Madam 'Jacq' Jacqueline | |
| Movie | 1986 | Women in Rock | Self (archive footage) | |
| Movie | 2025 | BP Fallon: Rock'n'Roll Wizard | Self | |
| Movie | 2009 | The Mystery of Claywoman | Simone | |
| Movie | 2025 | Ladies & Gentlemen... 50 Years of SNL Music | Self | |
| Movie | 2024 | The Warhol Effect | Self | |
| Movie | 2015 | The Viking of Sixth Avenue | | |
| Movie | 2014 | Blondie: Live at CBGB 1977 | Self | |
| Movie | 1999 | Beastie Boys: Tibetan Freedom Concert 1999 | | |
| TV Show | 1984 | Tales from the Darkside | | 1 |
| TV Show | 2001 | Friday Night with Jonathan Ross | Self - Guest | 1 |
| TV Show | 1952 | Today | Self | 1 |
| TV Show | 1972 | Musikladen | | 0 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 2008 | Markus Lanz | Self | 1 |
| TV Show | 2005 | Top of the Pops Reloaded | Self | 1 |
| TV Show | 2004 | The Paul O'Grady Show | | 1 |
| TV Show | 2007 | The Dame Edna Treatment | | 1 |
| TV Show | 1973 | Rock Concert | Self | 1 |
| TV Show | 1995 | MADtv | Self | 1 |
| TV Show | 1987 | Wiseguy | | 3 |
| TV Show | 2002 | V Graham Norton | Self | 1 |
| TV Show | 1994 | TOTP2 | Self | 1 |
| TV Show | 1976 | The Muppet Show | Self - Special Guest Star | 1 |
| TV Show | 2007 | The Singing Bee | | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2007 | Inas Nacht | Self | 1 |
| TV Show | 2020 | High Fidelity | Debbie Harry | 1 |
| TV Show | 1972 | The Midnight Special | Self - Blondie | 1 |
| TV Show | 2012 | She's Living for This | Debbie Harry | 1 |
| TV Show | 1996 | Sabrina, the Teenage Witch | Cassandra | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Musical Guest | 2 |
| TV Show | 1997 | Behind the Music | Self | 1 |
| TV Show | 2009 | RuPaul's Drag Race | Self - Guest Judge | 1 |
| TV Show | 1975 | Midi Première | Self - Blondie | 1 |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 1982 | Wogan | Self | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2012 | Song by Song | Self | 4 |
| TV Show | 2019 | Punk | Self | 2 |
| TV Show | 1981 | Entertainment Tonight | Self | 1 |
| TV Show | 2003 | Die ultimative Chartshow | Self | 1 |
| TV Show | 1998 | VH1 Divas | Self -Performer | 1 |
| TV Show | 2007 | The Graham Norton Show | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 1994 | Hi Octane | Self (as Deborah Harry) | 1 |
| TV Show | 1993 | The Adventures of Pete & Pete | Neighbor | 1 |
| TV Show | 1998 | Ein Herz für Kinder | Self | 1 |
| TV Show | 1978 | TV Party | | 7 |
| TV Show | 2011 | Berlin Live | Self - Performer | 1 |
| TV Show | 2007 | Seven Ages of Rock | Self | 7 |
| TV Show | 2015 | Difficult People | Kiki | 2 |
| TV Show | 1980 | America's Top 10 | herself | 1 |
| TV Show | 1995 | The Music Biz | Self | 1 |
