Retroville becomes ground zero for a meteor engraved with a mysterious alien message, which only the best and brightest(naturally, Jimmy) can translate. When he finally figures the message out, he and his friends are teleported into deep space and are forced to become contestants on an intergalactic reality game show, where the losers have their home planets destroyed.
Jimmy Neutron / Alien Actress / Alien Woman (voice)
Carl Wheezer/Mr. Wheezer/Mrs. Wheezer/Test Pilot/Announcer (voice)
Sheen Estevez / Army Guard (voice)
Goddard (voice)
Cindy Vortex (voice)
Libby Folfax (voice)
Meldar Prime (voice)
April (voice)
Sr. Estevez (voice)
Gorlock #2 / Brain #1 (voice)
Judy Neutron / Mrs. Vortex (voice)
Brain #2 / Mayor Quadar (voice)
Hugh Neutron / Emergency System / Gen. Abercrombie (voice)
Meldar Prime (singing voice)
Sr. Estevez (voice)
Bolbi Stroganofsky / British Tourist (voice)
Sam / Corky Shumatsu (voice)
Vendanna (voice)
