Following the temporary retreat of the Altana Liberation Army from the Kabuki District, the state of the war has seemingly improved. However, as the Oniwaban, Shinsengumi, and residents of the district combat the army's remnants, Edo's greatest inventor Gengai Hiraga is abducted. Responsible for causing the enemy's withdrawal by rendering their weapons useless, Gengai's nanomachine virus is now at risk of being shut down. Meanwhile, a laser capable of obliterating a planet is activated in Earth's orbit on the Liberation Army's mother ship. Another battle ensues when Shinsuke Takasugi and the rest of the Kiheitai arrive on the vessel to stop the weapon from firing. Forced to fight a war on two fronts, the Yorozuya and their allies must prevail on both sides to save Edo and the rest of the world.
Takasugi enters the fray, and he and the Kiheitai change the entire dynamic of the battle in the Heavenly Bird.
Kagura senses Yato presence and runs off to stop them, and she has some unexpected backup!
With the Earth's Altana reserves going berserk, and the Flame of Kagutsuchi nearly ready to fire, the Kiheitai are left with hard choices to make in order to prevent the destruction of Earth and the entire galaxy.
Ensho's past is revealed, and Takasugi revolves to make a final stand to take him down.
The story shifts back to Earth, where Utsuro has made the Altana ley lines go berserk. Some old, familiar faces rise up to combat it.
Shijaku presents his brother, Prince Hata, with an impossible choice. As he finally makes his decision, Hasegawa suggests a different solution.
As Sadaharu fights to quell the rampaging ley lines, the gang puts it all on the line to take down Utsuro.
The Odd Jobs are joined by old mutuals in their battle to save serializd. @Sudais is surprised by a side of humanity he had never seen before.
Two years have passed, and Gintoki has shut down the Odd Jobs business and gone off to do something only he can do. Shinpachi has other ideas, though.
Shinpachi is forced into a plot to assassinate the inaugural prime minister of Japan, Donald Zuramp!
Okita and Kagura's daughter (?) rekindle their rivalry, and Okita senses something is off. Meanwhile, Gintoki runs into an old friend.
Gintoki and Takasugi reveal to each other what they've been doing over the past two years, and decide to go save the one thing they never managed to save in the past: their teacher.
Now back in Edo, Gintoki doesn't know how to face his old friends, and so he decides to try and avoid running into any of them. However, that won't be easy.
Having caught Takasugi Shinsfake, the ladies' gang decides to teach him a lesson and try and get him to spill the beans on where Gintoki is. How will Shinsfake survive this?