When world-renowned wine critic Toyotaka Kanzaki passes away, he leaves behind an enviable and priceless wine collection. His will promises the entire estate to whoever can correctly guess the brand and vintage of the 12 greatest wines he selected, and the ultimate legendary bottle that stands atop them all, the "Drops of God". This sparks an intense battle of senses between Toyotaka's biological son, Shizuku Kanzaki, who has never tasted a drop of wine, and Issei Tomine, a brilliant young wine critic whom Toyotaka recently adopted. To defeat his rival, Shizuku must dive into the complex world of enology and awaken his dormant, god-gifted palate.
A beer company employee is caught up in a game of wine after his father's death.
Shizuku begins his search for the meaning of the vision he saw.
Shizuku begins his search for the first of the Twelve Apostles.
The first battle over the Twelve Apostles is held.
A strange man transfers to the newly-founded wine division at Taiyo beer.
Miyabi is reunited with an old love from school who wants to buy wine from Taiyo beer's wine division.
Shizuku gets help with Takasugi's challenge from Issei Tomine.
A mystery author comes to Shizuku about a strange bottle of wine.
The identity of the one who sent the threatening letter, as well as the Second Apostle, are revealed.
The battle for the Third Apostle begins, and a new member comes to the wine division.
The battle for the Third Apostle continues.
Louran's jealous rivals plot to separate her from Tomine.
Shizuku and Tomine search for their first loves to win the next Apostle battle.
Shizuku and Tomine work together to get back stolen wine.
Tomine and Shizuku work together to appraise an old wine collection.
Tomine and Shizuku climb the Matterhorn in search of the Fifth Apostle.